Sökning: "protein profiling"

Visar resultat 1 - 5 av 201 avhandlingar innehållade orden protein profiling.

  1. 1. Antibody based plasma protein profiling

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Ulrika Qundos; KTH.; KTH.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein profiling; plasma; antibody; affinity proteomics; biomark- ers; multiplex; assay development;

    Sammanfattning : This thesis is about protein profiling in serum and plasma using antibody suspension bead arrays for the analysis of biobanked samples and in the context of prostate cancer biomarker discovery. The influence of sample preparation methods on antibody based protein profiles were investigated (Papers I-III) and a prostate cancer candidate biomarker identified and verified (Papers III-V). LÄS MER

  2. 2. Validation of antibodies for protein profiling A study using immunohistochemistry on tissue microarrays

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Linda Paavilainen; Uppsala universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibody validation; monospecific antibodies; protein profiling; immunohistochemistry; tissue microarrays; western blot; fixatives; MEDICINE Morphology; cell biology; pathology Pathology; MEDICIN Morfologi; cellbiologi; patologi Patologi; Pathology; patologi;

    Sammanfattning : The field of proteomics has rapidly expanded due to the completion of the human genome sequence. This thesis validates affinity-purified monospecific antibodies of polyclonal origin, for protein profiling in a broad spectrum of normal tissues and cells. LÄS MER

  3. 3. Protein Profiling and Type 2 Diabetes

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Tea Sundsten; Uppsala universitet.; [2008]
    Nyckelord :Cell biology; Type 2 diabetes; Protein profiling; SELDI-TOF MS; Proteomics; Cellbiologi;

    Sammanfattning : Type 2 diabetes mellitus (T2DM) is a heterogeneous disease affecting millions of people worldwide. Both genetic and environmental factors contribute to the pathogenesis. The disease is characterized by alterations in many genes and their products. LÄS MER

  4. 4. DNA-Mediated Detection and Profiling of Protein Complexes

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Maria Hammond; Uppsala universitet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proximity ligation assay; Protein complexes; Protein interactions; Biomarkers; Prions; Antibodies; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Proteins are the effector molecules of life. They are encoded in DNA that is inherited from generation to generation, but most cellular functions are executed by proteins. Proteins rarely act on their own – most actions are carried out through an interplay of tens of proteins and other biomolecules. LÄS MER

  5. 5. Bead based protein profiling in blood

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Maja Neiman; KTH.; KTH.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affinity proteomics; protein array; suspension bead array; antigen; antibody; biomarker discovery; serology; selectivity; sensitivity; serum; plasma;

    Sammanfattning : This thesis is about protein profiling in blood-derived samples using suspension bead ar- rays built with protein affinity reagents, and the evaluation of binding characteristics and potential disease relation of such profiles.A central aim of the presented work was to discover and verify disease associated protein profiles in blood-derived samples such as serum or plasma. LÄS MER