Sökning: "Jonas von Hofsten"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Jonas von Hofsten.
1. Developmental and reproductive regulation of NR5A genes in teleosts
Sammanfattning : In mammals sex chromosomes direct and initiate the development of male and female gonads and subsequently secondary sex characteristics. In most vertebrates each individual is pre-destined to either become male or female. LÄS MER
2. Studies on the biological functions of interaction between components in Wnt, TGF-β and HIF pathways for cancer progression
Sammanfattning : Cancer is a disease that involves aggressive changes in the genome and aberrant signals between the living cells. Signalling pathways such as TGF-β (Transforming growth factor-β), Wnt, EGF (epidermal growth factor) and HIF (Hypoxia-inducible factor) evolved to regulate growth and development in mammals. LÄS MER
3. Genetic studies of zebrafish muscles : clues to protection in muscle disease
Sammanfattning : Muscular dystrophies (MDs) are caused by dysregulation of over 40 proteins but commonly share features of muscle weakness, myofiber death and regeneration, loss of ambulation and premature death. A MD involves a broken link anywhere in the connection from extracellular matrix through the sarcolemma to the sarcomere. LÄS MER
4. PARN - A Tale of A de-Tailor : Functional importance of poly(A) degradation in developmental and telomere biology disorders
Sammanfattning : Poly(A)-specific ribonuclease (PARN) is a eukaryotic 3’-5’exoribonuclease that removes poly(A) tails of many coding and non-coding RNAs. In this thesis, we have studied the physiological role of PARN. LÄS MER
5. BMP - a key signaling molecule in specification and morphogenesis of sensory structures
Sammanfattning : Cranial placodes are transient thickenings of the vertebrate embryonic head ectoderm that will give rise to sensory (olfactory, lens, and otic) and non-sensory (hypophyseal) components of the peripheral nervous system (PNS). In most vertebrate embryos, these four sensory placodes undergo invagination. LÄS MER