Sökning: "b-catenin"

Visar resultat 6 - 10 av 13 avhandlingar innehållade ordet b-catenin.

1. 6. Notch signalling in carcinogenesis : With special emphasis on T-cell lymphoma and colorectal cancer

   Författare :Jonas Ungerbäck; Peter Söderkvist; Ola Hermanson; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Notch signalling; T-cell lymphoma; colorectal cancer; Wnt signalling; transcription; Medical cell biology; Medicinsk cellbiologi;

   Sammanfattning : The Notch signalling pathway is an evolutionary conserved pathway, named after the Notch receptors, Notch1-4 in mammals, which upon cell-cell contact and ligand binding releases the intracellular domain (NICD). NICD translocates into the nucleus where it binds the transcriptional repressor RBP-Jk, which together with co-activators belonging to the Mastermind-like family of proteins form a transcriptional activation complex. LÄS MER

3. 7. Expression and novel function of CD43 in colon cancer cells

   Författare :Christian X Andersson; Göteborgs universitet; []
   Nyckelord :CD43; leukosialin; sialophorin; mucin; nuclear localization; nuclear signaling; Wnt-signaling; beta-catenin; regulated intramembrane cleavage; RIP; proteolytic cleavage;

   Sammanfattning : CD43 is a transmembrane protein containing an extracellular domain that is extensively O-glycosylated, and a relatively large intracellular domain with a conserved sequence between human, rat and mouse. It is frequently expressed in haematopoietic cell lines where it functions as a regulator of cell adhesiveness, a signal transducer and a cytoskeleton-interacting protein. LÄS MER

4. 8. Tumor progression in the ovary and colon. The interaction of Wnt-signaling, transcription and formation of prostaglandins

   Författare :Katarina Rask; Göteborgs universitet; []
   Nyckelord :CCAAT Enhancer Binding Proteins C EBPs ; Wingless Wnt Wnt signaling pathway; Cyclooxygenases COXs ; colorectal cancer CRC ; epithelial ovarian cancer EOC ;

   Sammanfattning : Alterations in cell-cell adhesion, intracellular signaling and transcriptional regulation are common events during transformation of cells to the malignant phenotype. Different cellular defense mechanisms, e.g. inflammatory responses, mediated by prostaglandins, have also been associated with tumor development. LÄS MER

5. 9. Influence of leukotriene D4 and cyclooxygenase-2 on cell survival

   Författare :Katarina Wikström; Malmö Experimentell patologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pathological anatomy; Patologi allmän ; General pathology; colorectal cancer; inflammation; apoptosis; LTD4; COX-2; patologisk anatomi;

   Sammanfattning : The pro-inflammatory effect of leukotrienes is an important element in the pathogenesis of multiple disorders, including asthma and inflammatory bowel diseases (IBD). A serious concern for IBD patients is the increased risk of developing colorectal cancer and since there seems to be a general connection between inflammation and cancer we hypothesised that LTD4 induced signalling events could be involved in increasing the tumourgenic potential of cells. LÄS MER

7. 10. Role of Wnt-5a in breast cancer

   Författare :Janna Sand-Dejmek; Malmö Experimentell patologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; General pathology; signal transduction; metastasis; adhesion; breast cancer; Syk; Wnt-5a; DDR1; pathological anatomy; Patologi allmän ; patologisk anatomi;

   Sammanfattning : Breast cancer is one of the most common cancer forms in the industrialized world. Only in Sweden, nearly 6000 women are diagnosed with breast cancer each year and 1/3 of them eventually succumb to the disease. LÄS MER