Sökning: "CD43"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet CD43.

  1. 1. Tumor biological aspects of the mucin-like glycoprotein CD43

    Författare :Sirle Laos; Göteborgs universitet; []
    Nyckelord :CD43; leukosialin; sialophorin; mucin; colon adenoma; proteolytic processing; ; NF-kappaB; p65; chemokine; p53; ARF; Fas; apoptosis; transformation;

    Sammanfattning : Cancer cells overexpress aberrant forms and amounts of mucins, which contribute to tumor development by regulating cell growth, survival, adhesion, invasion and immune responses. CD43, a type I transmembrane protein, is a mucin-like molecule expressed under normal physiological conditions by most hematopoietic cell types. LÄS MER

  3. 2. Expression and novel function of CD43 in colon cancer cells

    Författare :Christian X Andersson; Göteborgs universitet; []
    Nyckelord :CD43; leukosialin; sialophorin; mucin; nuclear localization; nuclear signaling; Wnt-signaling; beta-catenin; regulated intramembrane cleavage; RIP; proteolytic cleavage;

    Sammanfattning : CD43 is a transmembrane protein containing an extracellular domain that is extensively O-glycosylated, and a relatively large intracellular domain with a conserved sequence between human, rat and mouse. It is frequently expressed in haematopoietic cell lines where it functions as a regulator of cell adhesiveness, a signal transducer and a cytoskeleton-interacting protein. LÄS MER

  4. 3. Expression and functional significance of the leukocyte sialoglycoprotein (CD43) on subpopulations of human lymphocytes

    Författare :Margareta Wikén; Stockholms universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  5. 4. Studies on the biosynthesis of ABH and Lewis epitopes on O-glycans

    Författare :Jonas Löfling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Fucose; Lewis antigen; Blood group ABH; biosynthesis;

    Sammanfattning : ABH and Lewis antigens are carbohydrate epitopes (glycans) found on a wide variety of cell surfaces. They are involved in many biological processes, e.g transplantation rejection, bacterial and viral adhesion, cell-cell communication and metastasis. The in vivo synthesis of glycans is mediated by glycosyltransferases (GTs). LÄS MER

  7. 5. Antibody Feedback Regulation and T Cells

    Författare :Fredrik Carlsson; Birgitta Heyman; Alf Grandien; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fc receptors; B cell; T cell; antigen presentation; complement receptors; complement; IgE; IgG3; CD23; antibody; Immunology; Immunologi;

    Sammanfattning : Antibodies, passively administered or actively produced, regulate immune responses to the antigen they recognize. This phenomenon is called antibody-mediated feedback regulation. Feedback regulation can be positive or negative, resulting in >1000-fold enhancement or >99% suppression of the specific antibody response. LÄS MER