Sökning: "Wingless Wnt Wnt signaling pathway"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Wingless Wnt Wnt signaling pathway.

  1. 1. Tumor progression in the ovary and colon. The interaction of Wnt-signaling, transcription and formation of prostaglandins

    Författare :Katarina Rask; Göteborgs universitet; []
    Nyckelord :CCAAT Enhancer Binding Proteins C EBPs ; Wingless Wnt Wnt signaling pathway; Cyclooxygenases COXs ; colorectal cancer CRC ; epithelial ovarian cancer EOC ;

    Sammanfattning : Alterations in cell-cell adhesion, intracellular signaling and transcriptional regulation are common events during transformation of cells to the malignant phenotype. Different cellular defense mechanisms, e.g. inflammatory responses, mediated by prostaglandins, have also been associated with tumor development. LÄS MER

  3. 2. A frizzled quest to dissect the molecular pharmacology of WNT signaling : from biology to signaling mechanism(s)

    Författare :Elisa Arthofer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The wingless/int1 (WNT)/Frizzled (FZD) family of signal transduction pathways is highly conserved across species and controls essential physiological functions important for embryonic development, stem cell renewal, proliferation, differentiation, and cell polarity. Dysregulation of these signaling pathways leads to developmental abnormalities or other conditions such as inflammation, cancer, or neurological disorders. LÄS MER

  4. 3. Molecular aspects of parathyroid tumorigenesis : with focus on parafibromin and the Wnt pathway

    Författare :Christofer Juhlin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Primary hyperparathyroidism (PHPT) denotes the tumorous enlargement of one or several parathyroid glands and constitutes a common disorder, particularly pronounced among postmenopausal women. PHPT patients display hypercalcemia as a consequence of parathyroid hormone hypersecretion, and the symptomatology is habitually based on this metabolic aberrancy. LÄS MER

  5. 4. Targeting dysfunctional developmental signaling cascades as a tool for tailored therapy in embryonal tumors

    Författare :Cecilia Dyberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroblastoma and medulloblastoma are embryonal malignant tumors of the central and peripheral nervous systems, respectively. The overall survival for both diagnoses is 60-75% despite intense multimodal therapy. This warrants the search for novel therapeutic approaches. LÄS MER

  7. 5. Understanding and targeting the architecture in cancer : novel therapies in neuroblastoma and medulloblastoma

    Författare :Teodora Andonova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is the second leading cause of death worldwide after cardiovascular diseases. In Sweden, childhood cancer is the most common cause of death in children 1-14 years of age. Owing to advances in treatment and a better understanding of tumor biology, survival rates have increased to over 80% in most Western countries. LÄS MER