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Visar resultat 1 - 5 av 13 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Molecular Genetic Alterations In Endometrial And Ovarian Cancers

    Författare :Anjila Koul; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; KRAS; PTEN; TP53; Overexpression; Mutation; Microsatellite instability; Complex atypical hyperplasia; Endometrial cancer; Ovarian cancer; cancer; onkologi; Cytologi; cancerology; oncology; Cytology; CNS metastasis; Cytogenetic analysis; BRCA2; BRCA1; B-catenin; CDKN2A;

    Sammanfattning : Endometrial cancer is the most common gynecological cancer diagnosed in western countries. Complex atypical hyperplasia (CAH) reflects a state of hyperestrinism and its role as a precursor lesion of this cancer is established. LÄS MER

  3. 2. Involvement of Eicosanoid Signaling in Intestinal Epithelial Cell Survival

    Författare :John Öhd; Malmö Experimentell patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; General pathology; Tcf Lef; Bcl-2 family; b-catenin; 5-LO; apoptosis; cell survival; colorectal cancer; COX-2; LTD4; CysLT1 R; pathological anatomy; Patologi allmän ; patologisk anatomi;

    Sammanfattning : Eicosanoids are known to be involved in many different aspects of eukaryotic physiology and pathology. Notably, over the past 10 years much attention has been given to cyclooxygenase-2 (COX-2) due to its involvement in colorectal cancer. Less is known about the other major branch of arachidonic acid metabolism, namely the lipoxygenases (LO). LÄS MER

  4. 3. Endothelial differentiation and angiogenesis regulation

    Författare :Johan Dixelius; Björn Olsen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Angiogenesis; VEGFR-3; Laminin; endostatin; FGF-2; b-catenin; Genetik; Clinical genetics; Klinisk genetik; Molecular Medicine; molekylär medicin genetik och patologi ;

    Sammanfattning : Angiogenesis can be defined as the formation of new blood vessels from pre-existing ones. Angiogenesis is required for development and maintenance of our vascular system and thus of fundamental importance to our existence. LÄS MER

  5. 4. The impact of Wnt5a signaling and tumor associated macrophages in breast cancer

    Författare :Catharina Hagerling; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Wnt5a; E-cadherin; B-catenin; migration; invasion; turnor associated macrophages; CD163; CD68; turnor stroma;

    Sammanfattning : Breast cancer is the most common cancer among women worldwide with approximately 1.150.000 new cases each year and accounting for over 400.000 deaths per year. LÄS MER

  7. 5. LTD4 signalling via beta-catenin: a possible link between inflammation and cancer

    Författare :Maryna Mezhybovska; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LTD4; beta-catenin; colorectal cancer; CysLT1R; proliferation; inflammation;

    Sammanfattning : The pro-inflammatory mediator LTD4 is an important component in the pathogenesis of inflammatory conditions as inflammatory bowel diseases. Patients suffering from inflammatory bowel diseases face an increased risk of intestinal cancer development. LÄS MER