Sökning: "regulated intramembrane cleavage"

Hittade 2 avhandlingar innehållade orden regulated intramembrane cleavage.

  1. 1. Expression and novel function of CD43 in colon cancer cells

    Författare :Christian X Andersson; Göteborgs universitet; []
    Nyckelord :CD43; leukosialin; sialophorin; mucin; nuclear localization; nuclear signaling; Wnt-signaling; beta-catenin; regulated intramembrane cleavage; RIP; proteolytic cleavage;

    Sammanfattning : CD43 is a transmembrane protein containing an extracellular domain that is extensively O-glycosylated, and a relatively large intracellular domain with a conserved sequence between human, rat and mouse. It is frequently expressed in haematopoietic cell lines where it functions as a regulator of cell adhesiveness, a signal transducer and a cytoskeleton-interacting protein. LÄS MER

  3. 2. Functional domains in the Alzheimer's disease-associated presenilin 1 protein

    Författare :Hanna Laudon; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease (AD), the most common cause of dementia, is neuropathologically characterized by the presence of neurofibrillary tangles and amyloid plaques in the brain. Amyloid plaques are extracellular deposits primarily composed of the amyloid beta-peptide (Abeta). LÄS MER