Sökning: "antibody microarrays"

Visar resultat 11 - 15 av 32 avhandlingar innehållade orden antibody microarrays.

  1. 11. Protein Microarrays Based on Single Framework Recombinant Antibody Fragments (SINFABS) - Catcher and Carrier - A Crucial Combination

    Författare :Cornelia Steinhauer; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; probe; coupling chemistry; solid support; stability; scFv; antibody microarray; protein microarray; Biotechnology; Bioteknik;

    Sammanfattning : Antibody-based microarrays are among the novel class of rapidly evolving proteomic technologies. In recent years, antibody microarrays have emerged as a unique tool for high-throughput protein expression profiling with great promise within biomedicine and a wide range of potential applications, including disease diagnostics and biomarker discovery. LÄS MER

  3. 12. Tailoring of Antibody Arrays - Technical Advances Towards Global Proteome Analysis

    Författare :Linn Petersson; Institutionen för immunteknologi; []
    Nyckelord :antibody arrays; recombinant antibodies; scFv; miniaturization of arrays; immobilization of scFv; global proteome analysis; biomarker discovery;

    Sammanfattning : Abstract The number of cancer and autoimmune disease diagnoses increases in our society, which place high demands on the health care system. Being able to tailor treatments for each individual patient is called "Personalized medicine", and could revolutionize the care in the future. LÄS MER

  4. 13. Molecular serum portraits - A step towards personalized medicine

    Författare :Anders Carlsson; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GBM; SLE; breast cancer; Antibody microarrays; personalized medicine; serum biomarkers;

    Sammanfattning : Antibody microarray technology has the potential for playing a large roll in identifying serological biomarker panels for personalized medicine. The aim of this thesis, based on four original papers, was to investigate if information in the serum proteome could be extracted and used for diagnostic, classificational, prognostic or treatment predictive purposes in a range of diseases. LÄS MER

  5. 14. Mass Spectrometry and Affinity Based Methods for Analysis of Proteins and Proteomes

    Författare :Mårten Sundberg; Margareta Ramström; Jonas Bergquist; Christer Wingren; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; proteomics; microarray; protein; antibody; antigen; affinity; validation; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Proteomics is a fast growing field and there has been a tremendous increase of knowledge the last two decades. Mass spectrometry is the most used method for analysis of complex protein samples. It can be used both in large scale discovery studies as well as in targeted quantitative studies. LÄS MER

  7. 15. Proximity Ligation : Transforming protein analysis into nucleic acid detection through proximity-dependent ligation of DNA sequence tagged protein-binders

    Författare :Simon Fredriksson; Larry Gold; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; Proximity ligation; proteomics; SELEX; antibody; DNA microarray; Molekylärmedicin; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Molecular Medicine; molekylär medicin genetik och patologi ;

    Sammanfattning : A novel technology for protein detection, proximity ligation, has been developed along with improved methods for in situ synthesis of DNA microarrays. Proximity ligation enables a specific and quantitative transformation of proteins present in a sample into nucleic acid sequences. LÄS MER