Sökning: "analytical method"

Visar resultat 16 - 20 av 1238 avhandlingar innehållade orden analytical method.

  1. 16. Determination of biomarkers for lipid peroxidation and oxidative stress : Development of analytical techniques and methods

    Författare :Kristina Claeson Bohnstedt; Bo Karlberg; Niels Heegaard; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; capillary electrophoresis; mass spectrometry; electrospray; porous graphitic carbon; oxidative stress; lipid peroxidation; biomarker; malondialdehyde; hydroxynonenal; isoprostane; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Oxidative stress can be defined as a state of disturbance in the pro-oxidant/antioxidant balance in favour of the former, leading to potential damage. Processes associated with oxidative stress involve reactive oxygen species and radicals and can result in elevated levels of oxidatively modified or toxic molecules that can cause cellular malfunction, and even cell death. LÄS MER

  3. 17. Monitoring anti-infectives and antibiotic resistance genes : with focus on analytical method development, effects of antibiotics and national perspectives

    Författare :Ghazanfar Ali Khan; Jerker Fick; Klaus Kümmerer; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; method development; on-line solid phase extraction liquid chromatography mass spectrometry SPE LC-MS MS ; antibiotics; anti-infectives; constructed wetlands CWs ; denatured gradient gel electrophoresis DGGE ; percentage removal efficiency PRE ; shannon index; antibiotic resistance genes ARGs ; real-time polymerase chain reaction RT-PCR ; drug formulation facilities DFF ; wastewater; epidemiology; pandemic; influenza; compliance;

    Sammanfattning : Antibiotics are biologically active and are globally used in humans and animal medicine for treatment and in sub-therapeutic amounts as growth promoters in animal husbandry, aquaculture and agriculture. After excretion, inappropriate disposal and discharge from drug production facilities they enter into water bodies either as intact drugs, metabolites or transformed products. LÄS MER

  4. 18. Development of Field-adapted Analytical Methods for the Determination of New Antimalarial Drugs in Biological Fluids

    Författare :Niklas Lindegårdh; Karin Markides; Yngve Bergqvist; Anders Colmsjö; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; LC; liquid chromatography; biological samples; SPE; solid phase extraction; validation; antimalarial drugs; amodiaquine; piperaquine; atovaquone; dried blood spots; Analytisk kemi; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Sammanfattning : This thesis deals with the development of analytical methods for the determination of new antimalarial drugs in biological fluids. The goal was to develop methods that facilitate clinical studies performed in the field, such as capillary blood sampling onto sampling paper. LÄS MER

  5. 19. Development and improvement of methods for characterization of HPLC stationary phases

    Författare :Torgny Undin; Torgny Fornstedt; Jörgen Samuelsson; Anders Törncrona; Johan Ekeroth; Douglas Westerlund; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Adsorption isotherms; Elution by characteristic points; Inflection points; Single component adsorption; Elution by characteristic points method; Slope data; ECP-slope method; Adsorption; Adsorption energy distribution; Adsorption isotherms; AED; Characterization of adsorption processes; Chromatographic analysis; Chromatography; Hydrophobic-subtraction method HSM ; Hydrophobicity; Linear methods; Linear Models; Liquid chromatography; metoprolol; Non-linear methods; Nonlinear methods; phenol; priority journal; propranolol; Retention mechanism; reversed phase liquid chromatography; Solvation; Subtraction method; Thermodynamics; Chemistry with specialization in Surface Biotechnology; Kemi med inriktning mot ytbioteknik;

    Sammanfattning : High Performance Liquid Chromatography (HPLC) is a widely used tech-nique both for detecting and purifying substances in academy and in the industry. In order to facilitate the use of, and knowledge in HPLC, character-ization of stationary phases is of utmost importance. LÄS MER

  7. 20. Integrated Micro-Analytical Tools for Life Science

    Författare :Sara Bergström; Karin Markides; Marit Andersson; Marja-Liisa Reikkola; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Microdialysis; Multidimensional separation; Liquid chromatography LC ; Capillary electrophoresis CE ; Electrospray ionisation ESI ; Mass spectrometry MS ; Microchip device; Free drug concentration; Screening of microdialysates; Pattern recognition; Analytisk kemi; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Advances in life science require knowledge of active molecules in complex biological systems. These molecules are often only present for a certain time and at limited concentrations. LÄS MER