Sökning: "Microchip device"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Microchip device.

1. 1. Single Cell Investigations of the Functional Heterogeneity Within Immune Cell Populations : a Microchip-based Study

   Författare :Karolin Guldevall; Björn Önfelt; Hjalmar Brismar; Carsten Watzl; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biologisk fysik; Biological Physics;

   Sammanfattning : Immune cell populations are constantly divided into smaller and smaller subsets defined by newly emerging cellular markers. However, there is a growing awareness of the functional heterogeneities in between cells even within small populations, in addition to the heterogeneity over time. LÄS MER

3. 2. Development and Investigations of Novel Sample Preparation Techniques : Electrochemical Extraction and Evaluation of Miniaturized Analytical Devices Coupled to Mass Spectrometry

   Författare :Gustav Liljegren; Leif Nyholm; Jean Pettersson; Per Sjöberg; Ari Ivaska; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Electrochemical extraction; Solid-phase microextraction; Solid-phase extraction; Microchip; Mass spectrometry; Polypyrrole; Pressurized-fluid extraction; Preconcentration; Electrospray ionization; Analytisk kemi; Analytical chemistry; Analytisk kemi;

   Sammanfattning : Different sample preparation steps prior to a detection method are often essential in analytical chemistry. In this thesis, both static extractions and on-line coupled solid-phase extractions have been studied in combination with different detection techniques. LÄS MER

4. 3. Integrated Micro-Analytical Tools for Life Science

   Författare :Sara Bergström; Karin Markides; Marit Andersson; Marja-Liisa Reikkola; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Microdialysis; Multidimensional separation; Liquid chromatography LC ; Capillary electrophoresis CE ; Electrospray ionisation ESI ; Mass spectrometry MS ; Microchip device; Free drug concentration; Screening of microdialysates; Pattern recognition; Analytisk kemi; Analytical chemistry; Analytisk kemi;

   Sammanfattning : Advances in life science require knowledge of active molecules in complex biological systems. These molecules are often only present for a certain time and at limited concentrations. LÄS MER

5. 4. Ultrasound-assisted Interactions of Natural Killer Cells with Cancer Cells and Solid Tumors

   Författare :Athanasia Christakou; Martin Wiklund; Sabeth Verpoorte; KTH; []
   Nyckelord :Natural killer cell; cytotoxicity; heterogeneity; multiwell microchip; biocompatibility; ultrasonic cell manipulation; 3D cell culture; solid tumor; spheroid; high-resolution imaging; Biologisk fysik; Biological Physics;

   Sammanfattning : In this Thesis, we have developed a microtechnology-based method for culturing and visualizing high numbers of individual cells and cell-cell interactions over extended periods of time. The foundation of the device is a silicon-glass multiwell microplate (also referred as microchip) directly compatible with fluorescence microscopy. LÄS MER

7. 5. Development of Microchip-based Assays to Study Immune Cell Interactions at the Single Cell Level

   Författare :Karolin Guldevall; Björn Önfelt; Hjalmar Brismar; Antonio Barragan; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Bioengineering; Bioteknik;

   Sammanfattning : Immune cell populations are constantly divided into smaller and smaller subsets defined by newly emerging cellular markers. However, there is a growing awareness of the functional heterogeneities in between cells even within small populations, in addition to the heterogeneity over time. LÄS MER