Sökning: "Adenosine A2A receptor"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden Adenosine A2A receptor.

  1. 1. Striatal adenosine A2A receptors

    Författare :Per Svenningsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :caffeine; adenosine; A2A receptors; dopamine receptors; striatum; basal ganglia; immediate early genes; c-fos; NGFI-A; DARPP-32; in situ hybridization;

    Sammanfattning : The nucleoside adenosine exerts a modulatory action in the central nervous system by activating G-protein coupled receptors. Four such receptors are cloned and pharmacologically characterized: A1, A2A, A2B and A3. Caffeine, the most widely consumed psychostimulant, acts as an adenosine receptor antagonist predominantly on the first two. LÄS MER

  3. 2. Effects of adenosine and acetylcholine on the lacrimal gland

    Författare :Stina K. Carlsson; J. Peter Gierow; Sven Tågerud; Darlene Dartt; Linnéuniversitetet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Lacrimal gland; adenosine; adenosine receptors; signal transduction; exocrine secretion; tear film; dry eye; Sjögren’s syndrome; acetylcholine; mitogen activated protein kinase; p38; Cell biology; Cellbiologi; Ophtalmology; Oftalmologi; Cell and molecular biology; Cell- och molekylärbiologi; Cell biology; Cellbiologi; Molecular biology; Molekylärbiologi; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : A balanced tear film is essential for a healthy ocular surface. Insufficient tear production may result in dry eye, a common disorder in the elderly population. Dry eye causes significant discomfort in the patients and may lead to visual impairment and ocular infections. LÄS MER

  4. 3. Adenosine receptor/dopamine receptor interactions : molecular and biochemical aspects

    Författare :Maria Torvinen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adenosine; adenosine deaminase; A; receptor; A2A receptor; cell line; coimmunoprecipitation; confocal microscopy; dopamine; D1 receptor; D2 receptor; D3 receptor; heteromerization; internalisation; radioligand binding;

    Sammanfattning : The dopamine receptors have been shown to be involved in a variety of higher brain functions, such as motor control, cognition and affective states. Agonist and antagonists of dopamine receptors are widely used to treat disorders such as Parkinson's disease and schizophrenia, respectively. LÄS MER

  5. 4. Behavioural and biochemical pharmacology of adenosine/dopamine receptor/receptor interaction

    Författare :Roberto Rimondini-Giorgini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adenosine; A; receptors; A2A receptors; dopamine; D1 receptors; D2 receptors; mGluR receptors; striatum; immediately early genes; c-fos; junB; NGFI-A; microdialysis; receptor binding; in situ hybridisation;

    Sammanfattning : The neurotransmitter dopamine seems to be involved in neuropsychiatric diseases such as schizophrenia and Parkinson's disease. Direct blockade of dopamine receptors of the D2 subtype has been the hallmark of pharmacotherapy for schizophrenia since early 1950s. LÄS MER

  7. 5. Advances in Ligand Binding Predictions using Molecular Dynamics Simulations

    Författare :Henrik Keränen; Johan Åqvist; Jordi Villà i Freixa; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; free-energy perturbation; molecular dynamics; ligand binding; free-energy perturbation; linear interaction energy; binding free-energy; homology modeling; virtual screening; alanine scanning; amino acid mutagenesis; hERG; GPCR; adenosine receptor; serotonin receptor; BRICHOS; cruzain;

    Sammanfattning : Biochemical processes all involve associations and dissociations of chemical entities. Understanding these is of substantial importance for many modern pharmaceutical applications. In this thesis, longstanding problems with regard to ligand binding are treated with computational methods, applied to proteins of key pharmaceutical importance. LÄS MER