Sökning: "dopamine D 2 receptor"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden dopamine D 2 receptor.

  1. 1. Apoptosis And Excitotoxicity In The Death of Cultured And Grafted Dopaminergic Neurones

    Författare :Gabriele Schierle; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ac-YVAD-cmk; MK-801; flunarizine; N-methyl-D-aspartate; voltage-dependent calcium channels; Bcl-2; caspase; excitotoxicity; apoptosis; tyrosine hydroxylase; dopamine; Parkinson s disease; intracerebral transplantation; Poly ADP-ribose polymerase; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Over the past two decades, grafting of embryonic nigral tissue has developed into a feasible therapeutic strategy for Parkinson's disease (PD). It has become apparent that the degree of restoration of dopaminergic neurotransmission by the transplanted cells is highly correlated to the symptomatic relief. LÄS MER

  3. 2. Clozapine as a dopamine D₁ receptor agonist

    Författare :Peter Salmi; Leif Lindström; Stockholms universitet; []
    Nyckelord :psykologi; Psychology;

    Sammanfattning : Objectives'. The present study had two major objectives; [1] to examine the specific role of dopamine D, and DM receptors in body temperature regulation in rats, and [2] to examine in vivo dopamine D, and Dm receptor agonist/antagonist properties of clozapine by use of core temperature measurements.Methods'. LÄS MER

  4. 3. Pet imaging of two monoaminergic neurotransmitter systems in brain : studies of the norepinephrine transporter and dopamine D[2] receptor

    Författare :Nicholas Seneca; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Positron emission tomography (PET) has been widely used to study non-invasively function of the brain, pathophysiology of disease and aid in the development of new drugs. PET and selective radiolabeled molecules allow imaging of certain critical components of neurotransmission, such as pre-synaptic transporters and post-synaptic receptors in living brain. LÄS MER

  5. 4. Assessment of Graft Effects and Function in Cell Replacement Therapy for Parkinson's Disease

    Författare :Peter Hagell; Äldres hälsa och personcentrerad vård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; Neurology; measurement; psychometrics; perceived health; dyskinesias; assessment; striatum; positron emission tomography; dopamine; Parkinson s disease; transplantation;

    Sammanfattning : This explorative study aimed to apply, develop, and evaluate assessment methods at various levels in cell replacement therapy for Parkinson’s disease (PD). Observed motor effects in five grafted patients support that timed motor tasks and clinical ratings of parkinsonism are able to monitor motor function, but their psychometric properties need further attention. LÄS MER

  7. 5. Perinatal asphyxia in the rat : a morphological and functional analysis of the dopamine systems and dopamine-mediated behaviours in a novel experimental model

    Författare :Yong Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Rat; Perinatal asphyxia; Dopamine; Noradrenaline; Dopamine receptors; Substantia nigra; Ventral tegmental area; Striatum; Accumbens nucleus; Locomotor activity; Attention disorders; bFGF; Fos; pH; pyruvate; lactate; glutamate; aspartate.;

    Sammanfattning : Asphyxia during labour in the human being is one of the important paediatric complications which can lead to various degree of injuries in the central nervous system. No efficient therapy is available at present. LÄS MER