Sökning: "Two-State"

Visar resultat 6 - 10 av 46 avhandlingar innehållade ordet Two-State.

  1. 6. Folding of the Ribosomal protein S6 : The role of sequence connectivity, overlapping foldons, and parallel pathways

    Författare :Ellinor Haglund; Mikael Oliveberg; Neil Ferguson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein folding; protein stability; two-state folding; S6; chevron plot; transition state; parallell pathways; foldon; two-channel landscape; protein engineering; H D-exchange; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : To investigate how protein folding is affected by sequence connectivity five topological variants of the ribosomal protein S6 were constructed through circular permutation.  In these constructs, the chain connectivity (i.e. the order of secondary-structure elements) is changed without changing the native-state topology. LÄS MER

  3. 7. The birth and growth of the protein folding nucleus : Studies of protein folding focused on critical contacts, topology and ionic interactions

    Författare :Linda Hedberg; Mikael Oliveberg; Christopher Johnson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein folding; protein stability; two-state folding; chevron plot; transition-state movements; Hammond behaviour; topology; electrostatic interactions; pH dependence; mass-action; protein engineering; pKa; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Proteins are among the most complex molecules in the cell and they play a major role in life itself. The complexity is not restricted to just structure and function, but also embraces the protein folding reaction. LÄS MER

  4. 8. Modeling of Protein Folding and Genetic Networks

    Författare :Fredrik Sjunnesson; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Matematisk och allmän teoretisk fysik; thermodynamics; two-state folding; Protein folding; all-atom model; Mathematical and general theoretical physics; Kauffman model.; local update; Monte Carlo; classical mechanics; quantum mechanics; relativity; statistical physics; gravitation; klassisk mekanik; kvantmekanik; relativitet; statistisk fysik; termodynamik; Fysicumarkivet A:2003:Sjunnesson;

    Sammanfattning : Models for potein folding are developed and applied to peptides and small proteins with both α-helix and β-sheet structure. The energy functions, in which effective hydrophobicity forces and hydrogen bonds are taken to be the two central terms, are sequence-based and deliberately kept simple. LÄS MER

  5. 9. Process-induced disorder of pharmaceutical materials : Mechanisms and quantification of disorder

    Författare :Samaneh Pazesh; Göran Alderborn; Jonas Berggren; Niklas Sandler; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Milling; Comminution; Powder flow; Amorphisation; Raman spectroscopy; Atomic force microscopy; Plastic stiffness; Elastic stiffness; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : One of the most important prerequisites in the drug development is to attain a reproducible and robust product in terms of its nature, and its chemical and physical properties. This can be challenging, since the crystalline form of drugs and excipients can be directly transformed into the amorphous one during normal pharmaceutical processing, referred to as process-induced amorphisation or process-induced disorder. LÄS MER

  7. 10. Orienting West Mexico: The Mesoamerican World System 200-1200 CE

    Författare :Peter F. Jimenez Betts; Göteborgs universitet; []
    Nyckelord :HUMANIORA; HUMANITIES; Mesoamerica; Archaeology; World-Systems theory; World-Systems analysis; Nested Networks; West Mexico; Central Mexico; Early Classic; Epiclassic; Early Postclassic;

    Sammanfattning : As world-systems theory came to the fore in archaeology during the 1980s and 1990s, it became evident that the analysis of pre-capitalist core/periphery relations required modifications of this theory for its further use in the discipline. As a result, the comparative approach for world-systems analysis (Chase-Dunn and Hall 1997) discerned four interaction networks that defined pre-capitalist world-systems. LÄS MER