Sökning: "T-cell lymphoma"

Visar resultat 11 - 15 av 61 avhandlingar innehållade orden T-cell lymphoma.

  1. 11. CAR T cells for Immunotherapy of Cancer

    Författare :Tina Sarén; Magnus Essand; Martin Pule; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chimeric antigen receptor CAR -T cells; Cancer immunotherapy; NAP; Tonic signaling; T cell exhaustion; B cell lymphoma; clinical trial; glioblastoma;

    Sammanfattning : In recent years, immunotherapy has revolutionized cancer treatment by prolonging survival and even curing patients lacking other available therapies. Besides immune checkpoint inhibitors, one of the major advances is attributed to the success of chimeric antigen receptor (CAR)-T cell therapy in treating patients with B-cell malignancies. LÄS MER

  3. 12. T-cell competition as a mechanism for immunodominance and the role for IL-12 in CTL responses

    Författare :Per Grufman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CTL; Dendritic cells; Immunodominance; T-cell competition; IL- 12;

    Sammanfattning : Immunodominance is a process in which the immune response focuses on one or a few of all potential epitopes that exists within an antigen. The mechanisms for immunodominance have not yet been determined. LÄS MER

  4. 13. Mucosal T-cell and cytokine responses in Helicobacter pylori-infected duodenal ulcer patients

    Författare :Erika Strömberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Helicobacter pylori; mucosal immunology; antrum; duodenum; duodenal ulcer; asymptomatic; epithelial cells; cytokines; T cells;

    Sammanfattning : Helicobacter pylori colonizes the human stomach and areas of gastric metaplasia in the duodenum. The bacterium is the major cause of chronic active gastritis and peptic ulcer disease and is a risk factor for the development of gastric adenocarcinoma and lymphoma. LÄS MER

  5. 14. CD19-targeting CAR T Cells for Treatment of B Cell Malignancies : From Bench to Bedside

    Författare :Hannah Karlsson; Angelica Loskog; Karl-Johan Malmberg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; chimeric antigen receptors; CAR T cells; T cell therapy; immunotherapy; CD19; Bcl-2 family inhibitors; B cell malignancies; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : Immunotherapy for cancer is a young research field progressing at high speed. The first chimera of an antibody and a signaling chain was designed by Zelig Eshhar and was later further developed to enhance existing T cell therapy by combining a single-chain fragment of an antibody with the CD3 zeta chain of the TCR complex. LÄS MER

  7. 15. Posttransplant Lymphoproliferative Disorders : Studies of Epstein-Barr Virus, Regulatory T Cells and Tumor Origin

    Författare :Amelie Kinch; Karlis Pauksens; Gunilla Enblad; Eva Baecklund; Harald Holte; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PTLD; Lymphoma; Epstein-Barr Virus; EBV DNAemia; FoxP3; Treg; Microenvironment; Cell of Origin; Recipient; Transplantation; Immunosuppression; Hepatitis C; Survival; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Epstein-Barr virus (EBV) infects almost all humans and establishes lifelong latency in B cells. Posttransplant lymphoproliferative disorder (PTLD) is a rare but serious complication after transplantation triggered by immunosuppression and often related to EBV infection. LÄS MER