Sökning: "IL- 12"

Visar resultat 1 - 5 av 242 avhandlingar innehållade orden IL- 12.

1. 1. Glucocorticosteroid effects on cytokine production: studies in a glucocorticosteroid resistance model and in allergic airway disease

   Författare :Susanne Larsson; allergologi och palliativ medicin Lungmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GM-CSF; cytokine; glucocorticoids; budesonide; IL-2; IL-4; IL-12; asthma; allergic rhinitis; allergic airway inflammation; Respiratory system; Andningsorganen;

   Sammanfattning : Glucocorticosteroids (GCS) are potent anti-inflammatory drugs, probably due to inhibitory effects on cytokine production. However, a small number of asthma patients seem GCS-resistant. Pro-inflammatory cytokines, such as interleukin-2(IL-2) and IL-4, produced during allergic airway inflammation have been proposed to induce the resistance to GCS. LÄS MER

3. 2. Cytokines in Staphylococcus aureus arthritis. For better for worse

   Författare :Olof H. Hultgren; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Staphylococcus aureus; septic arthritis; sepsis; cytokines; IL-4; IL-12; TNF; LTa; IFN-g.;

   Sammanfattning : Septic arthritis is an inflammatory condition in joints caused by in situ residing bacteria accompanied by a septic reaction. Bacteria reach their target via the blood stream and the major human pathogen is Staphylococcus aureus. LÄS MER

4. 3. Innate and adaptive immunity in genital HSV-2 infection: Implications for vaccine development

   Författare :Ali M Harandi; Göteborgs universitet; []
   Nyckelord :genital herpes infection; natural antibody; CD4 T cells; CD8 T cells; IFN-g; IL-12; IL-18; CC chemokines; dendritic cells.;

   Sammanfattning : Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract mucosa and is the most common case of genital ulcers in humans. Despite numerous studies, little is known about the mechanisms involved in immune protection and no anti-herpes vaccine has been developed to date. LÄS MER

5. 4. Regulation of innate and adaptive immune responses by Gram-positive and Gram-negative bacteria

   Författare :Anna Martner; Göteborgs universitet; []
   Nyckelord :Gram-positive; Gram-negative bacteria; Streptococcus pneumoniae; IL-12; autolysin; pneumolysin; CD4 T cells; monocytes macrophages; dendritic cells;

   Sammanfattning : Bacteria are classified as Gram-positive or Gram-negative, depending on their cell wall structure. The role of the bacterial cell wall in immune regulation is the focus of the current work. Most Gram-positive bacteria stimulate monocytes to produce large amounts of IL-12. LÄS MER

7. 5. Commensal microbes, immune reactivity and childhood inflammatory bowel disease

   Författare :Cecilia Barkman; Göteborgs universitet; []
   Nyckelord :Inflammatory bowel disease; IBD; Pediatric; Childhood; Microbiota; T cells; B cells; cytokine; IL-12; monocytes; phagocytosis; intracellular signaling pathway; Crohn s disease; ulcerative colitis; children; flora;

   Sammanfattning : Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal inflammation of unknown etiology, but immune activation by the commensal microbiota probably plays a major role. The two major categories of IBD are ulcerative colitis and Crohn’s disease. LÄS MER