Sökning: "T cell immune response"

Visar resultat 26 - 30 av 638 avhandlingar innehållade orden T cell immune response.

  1. 26. CAR T cells for Immunotherapy of Cancer

    Författare :Tina Sarén; Magnus Essand; Martin Pule; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chimeric antigen receptor CAR -T cells; Cancer immunotherapy; NAP; Tonic signaling; T cell exhaustion; B cell lymphoma; clinical trial; glioblastoma;

    Sammanfattning : In recent years, immunotherapy has revolutionized cancer treatment by prolonging survival and even curing patients lacking other available therapies. Besides immune checkpoint inhibitors, one of the major advances is attributed to the success of chimeric antigen receptor (CAR)-T cell therapy in treating patients with B-cell malignancies. LÄS MER

  3. 27. Immune response in human tonsil tissue

    Författare :Karin Ågren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tonsillar hypertrophy; reeurrent tonsillitis; infectious mononueleosis; cytokine; immune response.;

    Sammanfattning : Pathogenic mechanisms responsible for tonsillar hypertrophy (TH) in children suffering from obstructive sleep apnea syndrome (OSAS) were studied and compared with children with recurrent tonsillitis (RT) and infectious mononucleosis (IM), respectively. In an initial study the clinical consequences of OSAS caused by TH was investigated. LÄS MER

  4. 28. T Cells and NK Cells in Coronary Artery Disease : Longitudinal and methodological studies in humans

    Författare :Karin Backteman; Jan Ernerudh; Lena Jonasson; Joachim Lundahl; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Coronary artery disease (CAD) is the leading cause of death worldwide and most often due to atherosclerosis. Atherosclerosis is a chronic inflammatory process that involves the arteries, inclouding those that supply blood to the heart muscle. LÄS MER

  5. 29. Regulation of CNS inflammation upon T cell interaction with CNS resident cells

    Författare :Ingrid Teige; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; neurofysiologi; neuropsykologi; Neurologi; neurophysiology; neuron; glia; CNS; T cell; cytokine; immunoregulation; MS; EAE;

    Sammanfattning : Multiple Sclerosis (MS), is a neurologic, autoimmune disease characterized by CNS immune cell infiltration and demyelination. To experimentally study MS, we have utilized the mouse model Experimental Autoimmune Encephalomyelitis (EAE). EAE is induced through immunization with myelin antigens, which elicits an autoreactive Th1 cell response. LÄS MER

  7. 30. The ups and downs of T cells The role of costimulatory molecules in the modulation of T cell responses

    Författare :Christina Olsson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; transplantation; serology; CD28; costimulation; CD152; IL-2; NF-kB; AP-1; superantigen; Immunology; T cell; serologi;

    Sammanfattning : T cell activation requires the combination of antigen in the context of MHC and costimulatory molecules to induce a functional immune response. For our studies, we primarily utilized superantigens (SAg) that bind MHC class II molecules as first signal. LÄS MER