Visar resultat 1 - 5 av 64 avhandlingar innehållade ordet CD28.
Sammanfattning : Linomide is a potent immunomodulator that has been shown to inhibit autoimmunity in several animal models of autoimmune disease. We have approached the cellular and molecular mechanism of Linomide by investigating its effect on thymocyte development and its capacity to modulate the expression of activation markers on antigen presenting cells (APCs). LÄS MER
Sammanfattning : The most important prognostic factor in breast cancer is the axillary lymph node status. The sentinel node biopsy (SNB) is reported to stage the axilla with an accuracy > 95 % in early breast cancer. Tumour-related perturbation of T-cell function has been observed in patients with malignancies, including breast cancer. LÄS MER
3. The ups and downs of T cells The role of costimulatory molecules in the modulation of T cell responses
Sammanfattning : T cell activation requires the combination of antigen in the context of MHC and costimulatory molecules to induce a functional immune response. For our studies, we primarily utilized superantigens (SAg) that bind MHC class II molecules as first signal. LÄS MER
Sammanfattning : In affinity protein biotechnology the selective bindingbetween a chosen protein and an interacting biomolecule isutilized for a variety of applications including bioseparation,detection and therapy. Traditionally, affinity proteinsrecruited for such applications have been derived from naturalproteins or immunoglobulins generated via immunization routes. LÄS MER
5. Involvement of T lymphocyte subsets in the rejection of murine tumors by syngeneic or autologous hosts
Sammanfattning : Involvement of T Iymphocyte subsets in the rejection of murinetumors by syngeneic or autologous hosts Tao Wen The aim of this thesis is to study the requirement of CD4+ and CD8+ T Iymphocytesubset, CD28 costimulatory molecule and p56kk for the rejection of syngeneic tumorgrafts, and the autochthonous tumors induced by Moloney murine sarcoma virus. Italso addresses the role of CD4+ and CD8+ T subsets with regard to the polyomaviruspersistence and tumor development. LÄS MER