Sökning: "Schistosoma mansoni"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Schistosoma mansoni.

  1. 1. Immunopathogenesis of schistosomiasis mansoni : Immunity and pathology in a primary and a secondary infection following chemotherapy in the mouse and the baboo models

    Författare :Idle Omar Farah; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Baboon; BALB c mice; Chemotherapy; Cytokines; Fibrosis; Granuloma; Modulation; Pathology; Reinfection; Schistosoma mansoni; Th1; Th2; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Medicine; medicin;

    Sammanfattning : This thesis describes a series of experiments aimed at elucidating the mechanisms ofimmunity and pathology elicited by both a primary infection and a reinfection exposure toSchistosoma mansoni following chemotherapy. The effects of a single large cercarial doseand a cumulatively equivalent dose, administered as multiple small doses are compared. LÄS MER

  2. 2. Immunoregulation and cytokine production during Schistosoma mansoni infection

    Författare :Marika Kullberg; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  3. 3. Prediction of 3D structures of oligosaccharides. Methodological development and studies on saccharide antigens of interest for vaccine design

    Författare :Jimmy Rosen; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Oligosaccharide; conformation; 3D structure; O-antigen; Shigella dysenteriae; Escherichia coli; Burkholderia cepacia; Schistosoma mansoni; filtered systematic search; genetic algorithm;

    Sammanfattning : This thesis presents 3D structure predictions of five immunologically active surfacepolysaccharides of pathogens, which are of interest as targets for development of glycoconjugatevaccines. Furthermore it describes two methods which have been used for theconformational predictionsThe Shigella dysenteriae type 2 Oantigenwas predicted to form a compact helicalstructure with three repeating pentasaccharide units per turn. LÄS MER

  4. 4. Molecular dissection of established and proposed members of the Op18/Stathmin family of tubulin binding proteins

    Författare :Kristoffer Brännström; Martin Gullberg; Fredrik Ivars; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Op18 Stathmin; Sm16; tubulin; microtubule; schistosoma mansoni; Molecular biology; Molekylärbiologi;

    Sammanfattning : My initial aim was a functional analysis of the conserved Op18/stathmin family of microtubule-regulators, which includes the ubiquitous cytosolic Op18 protein and the neural membrane-attached RB3 and SCG10 proteins. The solved X-ray structure has shown that these proteins form a complex with tubulin -heterodimers via two imperfect helical repeats, which result in two head-to-tail aligned heterodimers in a tandem-tubulin complex. LÄS MER

  5. 5. Helminths and Immunity against Tuberculosis

    Författare :Daniel Elias; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; tuberculosis; BCG; helminths; immunomodulation; vaccination;

    Sammanfattning : The efficacy of Bacille Calmette Gueri n (BCG) is low and incidence of tuberculosis (TB) is high in those areas where helminths are endemic. Protection against tuberculosis requires strong cell mediated immunity while chronic helminth infections induce responses characterized by dominant Th2 responses as well as up-regulated regulatory T cell activity. LÄS MER