Sökning: "Th1"

Visar resultat 1 - 5 av 235 avhandlingar innehållade ordet Th1.

  1. 1. Genital tract CD4+ T cells for vaccination and protection against Chlamydia trachomatis

    Författare :Ellen Marks; Göteborgs universitet.; Gothenburg University.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chlamydia; T cell differentiation; genital tract; vaccination; costimulation; Th1; Th2; Th17; Tregs;

    Sammanfattning : Vaccination strategies for protection against sexually transmitted diseases (STDs) are lacking due to an incomplete understanding of genital tract T cell responses. This thesis dissects the generation of T helper subsets, including the recently discovered Th17 subset, during genital tract infection with a common sexually transmitted pathogen, Chlamydia trachomatis, and addresses vaccine requirements for the generation of genital tract CD4+ T cell immunity. LÄS MER

  2. 2. Effect of thimerosal on the murine immune system especially induction of systemic autoimmunity

    Detta är en avhandling från Institutionen för molekylär och klinisk medicin

    Författare :Said Havarinasab; Per Hultman; Klas Nordlind; [2006]
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; thimerosal; ethylmercury; autoimmunity; mice; immunosuppression; Th1; Th2; VETERINARY MEDICINE Pathology; VETERINÄRMEDICIN Patologi;

    Sammanfattning : The organic mercury compound ethylmercurithiosalicylate (thimerosal), an antiseptic and a preservative, has recently raised public health concern due to its presence in vaccines globally. Thimerosal dissociates in the body to thiosalicylate and ethyl mercury (EtHg), which is partly converted to inorganic mercuric mercury (Hg2+). LÄS MER

  3. 3. Mechanistic studies of the adjuvant effects of CTA1-DD and the native cholera toxin: Impact of cell targeting and tissue localization

    Detta är en avhandling från Göteborg : University of Gothenburg

    Författare :Johan Mattsson; Göteborgs universitet.; Gothenburg University.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vaccines; adjuvants; cholera toxin; germinal center; CTA1-DD; follicular dendritic cells; denritic cells; Th1; Th2; Th17; complement;

    Sammanfattning : Vaccines are the most effective means of preventing infectious diseases and improving global health. However, few vaccines have successfully been developed for protection at mucosal surfaces where most pathogens gain access. LÄS MER

  4. 4. Immunopathogenesis of schistosomiasis mansoni : Immunity and pathology in a primary and a secondary infection following chemotherapy in the mouse and the baboo models

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Idle Omar Farah; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Baboon; BALB c mice; Chemotherapy; Cytokines; Fibrosis; Granuloma; Modulation; Pathology; Reinfection; Schistosoma mansoni; Th1; Th2; Fysiologi och anatomi; MEDICINE Physiology and pharmacology; MEDICIN Fysiologi och farmakologi; Medicine; medicin;

    Sammanfattning : This thesis describes a series of experiments aimed at elucidating the mechanisms ofimmunity and pathology elicited by both a primary infection and a reinfection exposure toSchistosoma mansoni following chemotherapy. The effects of a single large cercarial doseand a cumulatively equivalent dose, administered as multiple small doses are compared. LÄS MER

  5. 5. Immune modulation in serous epithelial ovarian cancer focus on the role of tumor-derived exosomes

    Detta är en avhandling från Umeå : Umea University

    Författare :Alireza Labani Motlagh; Lucia Mincheva-Nilsson; Ola Winqvist; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ovarian cancer; EOC; HGSC; exosomes; NKG2D; MICA B; ULBP; DNAM-1; PVR; nectin-2; lncRNAs; immune suppression; anti-tumor immunity; NK-cell cytotoxicity; cytokines; Th1; Th2; T regulatory response; inflammation; tumor microenvironment;

    Sammanfattning : Serous epithelial ovarian cancer (EOC) is a potent suppressor of the immune defense. Here, we studied interactions between EOC and the immune system that lead to escape from tumor immune surveillance. LÄS MER