Sökning: "Burkholderia cepacia"
Hittade 4 avhandlingar innehållade orden Burkholderia cepacia.
1. Computational analysis of oligosaccharide conformations – methodological development, applied studies, and design of glycomimetics
Sammanfattning : Carbohydrates are the most abundant class of biomolecules. Besides their roles as structural elements and energy storage, they are involved in signaling and recognition processes. Their functions and activities depend on their preferred conformations. LÄS MER
2. Prediction of 3D structures of oligosaccharides. Methodological development and studies on saccharide antigens of interest for vaccine design
Sammanfattning : This thesis presents 3D structure predictions of five immunologically active surfacepolysaccharides of pathogens, which are of interest as targets for development of glycoconjugatevaccines. Furthermore it describes two methods which have been used for theconformational predictionsThe Shigella dysenteriae type 2 Oantigenwas predicted to form a compact helicalstructure with three repeating pentasaccharide units per turn. LÄS MER
3. Bacterial colonisation and infection of the lower airways in cystic fibrosis : a microbiological and clinical study
Sammanfattning : Pulmonary deterioration has remained the major cause of mortality in cystic fibrosis (C17) patients despite the considerable improvement of their survival due to more efficient therapy and centralised care. The progression of the CF lung disease is correlated to inflection with a limited number of colonising bacterial species. LÄS MER
4. Asymmetric transformation of ß- and γ-functionalized alcohols : Study of combined ruthenium-catalyzed racemization and enzymatic resolution
Sammanfattning : The major part of this thesis describes the asymmetric synthesis of β- and γ-amino alcohols through the combination of ruthenium catalyzed racemization and enzymatic kinetic resolution. The dynamic kinetic resolution, DKR, protocol for chlorohydrins was improved by employing Bäckvall’s catalyst, which is a base activated racemization catalyst, in combination with Burkholderia cepacia lipase. LÄS MER