Sökning: "complete linkage"

Visar resultat 1 - 5 av 36 avhandlingar innehållade orden complete linkage.

  1. 1. Genetics of the carbohydrate-deficient glycoprotein syndrome type Ia

    Författare :Cecilia Bjursell; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CDG Ia; PMM2; chromosome 16; linkage; linkage disequilibrium; prenatal diagnosis;

    Sammanfattning : In recent years, a revolution in the development of new techniques have made it possible to perform genetic studies of inherited disorders without prior knowledge about the gene product or the function of the gene. The techniques include linkage studies, allelic association studies, physical mapping and the sequencing of candidate genes for finding disease causing mutations. LÄS MER

  2. 2. Pointwise and Genomewide Significance Calculations in Gene Mapping through Nonparametric Linkage Analysis: Theory, Algorithms and Applications

    Författare :Lars Ängquist; Matematisk statistik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; programming; actuarial mathematics; Statistik; cytogenetics; Genetik; cytogenetik; Mathematics; Matematik; Statistics; operations research; Genetics; ROC curves; conditioning loci; optimal score functions; noncentrality parameter; cost adjusted relative efficiency; exponential tilting; importance sampling; Monte Carlo simulation; normal approximation; crossover rate; process maximum; analytical approximation; significance calculations; NPL score; conditional linkage analysis; two-locus linkage analysis; Allele sharing; aktuariematematik; operationsanalys; programmering; gene-gene interaction; composite hypotheses; genetic disease models; classes of score functions; nonparametric linkage analysis;

    Sammanfattning : In linkage analysis or, in a wider sense, gene mapping one searches for disease loci along a genome. This is done by observing so called marker genotypes (alleles) and phenotypes (affecteds/unaffecteds) of a pedigree set, i.e. LÄS MER

  3. 3. Progress in Hierarchical Clustering & Minimum Weight Triangulation

    Författare :Drago Krznaric; Institutionen för datavetenskap; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; computer technology; Systems engineering; minimum spanning tree; complete linkage; hierarchical clustering; minimum weight triangulation; greedy triangulation; Data- och systemvetenskap;

    Sammanfattning : In this thesis we study efficient computational methods for geometrical problems of practical importance and theoretical interest. The problems that we consider are primarily complete linkage clustering, minimum spanning trees, and approximating minimum weight triangulation. Below is a list of the main results proved in the thesis. LÄS MER

  4. 4. Genetics of pain : studies of migraine and pain insensitivity

    Författare :Anna Norberg; Monica Holmberg; Arn van den Maagdenberg; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Migraine; pain insensitivity; susceptibility genes; genome-wide scan; linkage; polymorphism; association; HSAN V; nerve growth factor; neurite outgrowth; Medical genetics; Medicinsk genetik;

    Sammanfattning : Pain is a major public health issue throughout the world. Increased understanding of the different forms of pain and identification of susceptibility genes could contribute to improved treatments. LÄS MER

  5. 5. Consequences of the Domestication of Man’s Best Friend, The Dog

    Författare :Susanne Björnerfeldt; Carles Vilà; Elena Jazin; Daniel Bradley; Uppsala universitet; []
    Nyckelord :Molecular genetics; mitochondrial genome; Y chromosome; microsatellites; disruptive selection; breed structure; whole genome amplification; gene flow; linkage disequilibrium; Canis familiaris; Canis lupus; Genetik;

    Sammanfattning : The dog was the first animal to be domesticated and the process started at least 15 000 years ago. Today it is the most morphologically diverse mammal, with a huge variation in size and shape. LÄS MER