Sökning: "conformation"

Visar resultat 1 - 5 av 431 avhandlingar innehållade ordet conformation.

  1. 1. Aβ Conformation Dependent Antibodies and Alzheimer's Disease

    Författare :Dag Sehlin; Lars Lannfelt; Frida Ekholm Pettersson; David Teplow; Uppsala universitet; []
    Nyckelord :Alzheimer s disease; amyloid-beta; protofibrils; conformation; monoclonal antibody; ELISA; MEDICINE; MEDICIN; Geriatrics; Geriatrik;

    Sammanfattning : Soluble intermediates of the amyloid-β (Aβ) aggregation process are suggested to play a central role in the pathogenesis of Alzheimer’s disease (AD) by causing synaptic dysfunction and neuronal loss. In this thesis, soluble Aβ aggregates have been studied with a particular focus on the Aβ protofibril, which has served as the antigen for developing conformation dependent monoclonal antibodies. LÄS MER

  2. 2. Polyelectrolyte adsorption on oppositely charged surfaces - Conformation and adsorption kinetics

    Författare :Lars-Erik Enarsson; Lars Wågberg; KTH; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Polyelectrolyte adsorption; adsorption kinetics; adsorption isotherms; conformation; bridging; stagnation point adsorption reflectometry; quartz crystal microgravimetry; polyelectrolyte titration; cationic polyacrylamide; cationic dextran; colloidal silica; silica surfaces; pulp; Chemistry; Kemi;

    Sammanfattning : Denna avhandling presenterar experimentella studier av polyelektrolytadsorption på motsatt laddade ytor, där substrat av både kiseloxid och blekt barrsulfatmassa har använts. Ett huvudsakligt syfte med denna forskning var att karaktärisera konformationen hos adsorberade skikt av katjonisk polyakrylamid (CPAM) i jämförelse med katjonisk dextran (Cdextran) och relatera denna information till inbindningskapaciteten av kolloidal kiselsyra. LÄS MER

  3. 3. Properties of stabilizers in colloidal dispersions

    Författare :Catherine Boissier; Chalmers University of Technology; []
    Nyckelord :surfactants; conformation; polymers; NMR relaxometry; exchange dynamics; residence times; adsorption; polymer-surfactant interaction; NMR diffusometry;

    Sammanfattning : Surfactants and polymers are frequently used as stabilizers in colloidal dispersions. Depending on their solubility and the interactions in their local environment, their tendency to remain adsorbed on a surface will differ. LÄS MER

  4. 4. Prediction of 3D structures of oligosaccharides. Methodological development and studies on saccharide antigens of interest for vaccine design

    Författare :Jimmy Rosen; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Oligosaccharide; conformation; 3D structure; O-antigen; Shigella dysenteriae; Escherichia coli; Burkholderia cepacia; Schistosoma mansoni; filtered systematic search; genetic algorithm;

    Sammanfattning : This thesis presents 3D structure predictions of five immunologically active surfacepolysaccharides of pathogens, which are of interest as targets for development of glycoconjugatevaccines. Furthermore it describes two methods which have been used for theconformational predictionsThe Shigella dysenteriae type 2 Oantigenwas predicted to form a compact helicalstructure with three repeating pentasaccharide units per turn. LÄS MER

  5. 5. Structure, dynamics and reactivity of carbohydrates : NMR spectroscopic studies

    Författare :Jerk Rönnols; Göran Widmalm; Mikael Bols; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; Conformation; NMR spectroscopy; Hydrogen bond; Organic Chemistry; organisk kemi;

    Sammanfattning : The main focus of this thesis is on the ring conformations of carbohydrate molecules; how the conformational equilibria and the rates of the associated interconversions are affected by the molecular constitution and their surroundings.The conformational equilibria of a group of amine linked pseudodisaccharides, designed as potential glycosidase inhibitors, comprising α-D-altrosides are described in Chapter 3. LÄS MER