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Visar resultat 16 - 20 av 155 avhandlingar som matchar ovanstående sökkriterier.

1. 16. Beyond AMPA and NMDA: Slow synaptic mGlu/TRPC currents : Implications for dendritic integration

   Författare :Marcus Petersson; Erik Fransén; Abdel El Manira; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; transient receptor potential; TRP; metabotropic glutamate receptor; mGlu1 5; dendritic integration; synaptic activation; temporal summation; low-frequency; entorhinal cortex; mathematical model; computational neuroscience; Computer science; Datavetenskap;

   Sammanfattning : In order to understand how the brain functions, under normal as well as pathological conditions, it is important to study the mechanisms underlying information integration. Depending on the nature of an input arriving at a synapse, different strategies may be used by the neuron to integrate and respond to the input. LÄS MER

3. 17. Neuronal Cell Death and Restoration in the Basal Ganglia: Implications for Huntington's and Parkinson's diseases

   Författare :Oskar Hansson; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; basal ganglia; Parkinson s disease; Huntington s disease; neural transplantation; restoration; NMDA receptor; excitotoxicity; calcium; caspase; neuronal cell death; apoptosis; transgenic mouse; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : Huntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia and extensive striatal neuronal death. The mechanism through which the widely expressed mutant huntingtin mediates striatal neurotoxicity is unknown. Excitotoxicity, i.e. LÄS MER

4. 18. Endoplasmic Reticulum Dynamic Structural Changes in Neurons: The Fission-Fusion Phenomena

   Författare :Krzysztof Kucharz; Sektion IV; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fragmentation; fission; endoplasmic reticulum; neurons; FRAP; primary cultures; organotypic slice cultures; in vivo; in situ; calcium; fusion; NMDA receptor; 2-photon microscopy; confocal microscopy;

   Sammanfattning : The endoplasmic reticulum (ER) is crucial for protein synthesis and protein maturation, is involved in cell stress and serves in neurons as the major intracellular Ca2+ store. Neuronal ER forms a continuous network of cisterns and tubules extending from soma to a subset of dendritic spines. LÄS MER

5. 19. The Biophysics of Na+,K+-ATPase in neuronal health and disease

   Författare :Evgeny E. Akkuratov; Hjalmar Brismar; Anita Aperia; Stefan Wennmalm; Poul Nissen; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Na ; K -ATPase; NMDA receptor; ouabain; phosphoproteome; oligomerization; rapid-onset dystonia-parkinsonism; Biologisk fysik; Biological Physics;

   Sammanfattning : Na+,K+-ATPase is one of the most important proteins in the mammalian cell. It creates sodium and potassium gradients which are fundamental for the membrane potential and sodium-dependent secondary active transport. LÄS MER

7. 20. Labelling of nucleoside analogues and NMDA receptor antagonists with 11C

   Författare :Linda Samuelsson; Uppsala universitet; []
   Nyckelord :;

   Sammanfattning : .... LÄS MER