Sökning: "Huntington s disease"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Huntington s disease.

  1. 1. Energy metabolism as a target for new treatment strategies in Huntington’s disease

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Marie Sjögren; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington´s disease; Energy metabolic alteration; Weight loss; Skeletal muscle; Adipose tissue; R6 2; Ghrelin; Liraglutide;

    Sammanfattning : Huntington´s disease (HD) is a fatal inherited neurodegenerative disorder caused by a CAG triplet repeat expansion in the huntingtin (HTT) gene and characterized by cognitive and motoric dysfunctions as well as psychiatric problems. Accumulating evidence, however, suggests altered energy metabolism and a hyper-catabolic state as key features of HD pathology. LÄS MER

  2. 2. Pericytes in Neurodegeneration

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Thomas Padel; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pericyte; Parkinson disease; Huntington Disease; PDGF-BB; RGS5;

    Sammanfattning : .... LÄS MER

  3. 3. Towards a Novel Treatment of Huntington´s Disease

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Clinical Neuroscience

    Författare :Mouna Esmaeilzadeh; Karolinska Institutet.; Karolinska Institutet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The function of the human brain is based on complex interactions between billions of neurons. The brain function declines as a result of normal aging, but is also disturbed in neuropsychiatric and neurodegenerative disorders. LÄS MER

  4. 4. Fluorescent thiophene-based ligands for detection and characterization of disease-associated protein aggregates

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Therése Klingstedt; Linköpings universitet.; Linköpings universitet.; [2013]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : In this thesis the unique optical properties of fluorescent ligands termed luminescent conjugated oligothiophenes (LCOs) have been used to study a variety of protein aggregates associated with human protein misfolding disease. This heterogeneous group of diseases contains well known and fatal members such as Alzheimer´s and Huntington´s disease and the development of sensitive tools for the detection and characterization of protein aggregates is crucial for unravelling the complexity of these pathologies. LÄS MER

  5. 5. Characterization of brn1.2 and corticotropin-releasing hormone genes in zebrafish

    Detta är en avhandling från Stockholm : Karolinska Institutet, Biosciences and Nutrition

    Författare :Gayathri Chandrasekar; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The zebrafish (Danio rerio), a tropical fresh water fish originally found in the rivers of India and Bangladesh has become a popular vertebrate model system over the last decade. The rapid sequencing of the zebrafish genome together with the latest advances in forward and reverse genetics has made this model organism more fascinating as it can be used to decipher the genetic mechanisms involved in the vertebrate development. LÄS MER