Sökning: "oligomerization"

Visar resultat 1 - 5 av 76 avhandlingar innehållade ordet oligomerization.

  1. 1. Oligomerization of human and bacterial frataxin : Structural and functional studies

    Författare :Mostafa Abdalkhalik; Biokemi och Strukturbiologi; []
    Nyckelord :Frataxin; Friedreich’s ataxia; iron; reactive oxiden species; protein oligomerization; SAXS; EM; cross-linking; XAFS; nano- DSF;

    Sammanfattning : Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by defeciency in frataxin, a highly conserved protein central to iron homeostasis in mirochondria. The function of frataxin is related to its capability to bind, store and deliver iron to different biochemical process such as iron-sulfur cluster assembly and heme biosynthesis. LÄS MER

  3. 2. Plant UDP-glucose Pyrophosphorylase : Function and Regulation

    Författare :Meng Meng; Leszek Kleczkowski; Javier Pozueta-Romero; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; UDP-glucose pyrophosphorylase; carbohydrate metabolism; in vivo regulation; T-DNA knockout; heterologous expression; isozyme; mutagenesis; kinetic property; oligomerization; Plant physiology; Växtfysiologi;

    Sammanfattning : UDP-glucose pyrophosphorylase (UGPase) is an important enzyme of carbohydrate metabolism in all living organisms. The main aim of this thesis was to investigate the function and regulation of plant UGP genes as well as the UGPase proteins. LÄS MER

  4. 3. UDP-sugar metabolizing pyrophosphorylases in plants : formation of precursors for essential glycosylation-reactions

    Författare :Daniel Decker; Leszek A. Kleczkowski; Henrik Vibe Schelle; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chemical library screening; Cell wall synthesis; Glycosylation; Nucleotide sugars; Oligomerization; Protein structure; Reverse chemical genetics; Sugar activation; UDP-sugar synthesis; biokemisk farmakologi; biochemical pharmacology; biokemi; Biochemistry; biology; biologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : UDP-sugar metabolizing pyrophosphorylases provide the primary mechanism for de novo synthesis of UDP-sugars, which can then be used for myriads of glycosyltranferase reactions, producing cell wall carbohydrates, sucrose, glycoproteins and glycolipids, as well as many other glycosylated compounds. The pyrophosphorylases can be divided into three families: UDP-Glc pyrophosphorylase (UGPase), UDP-sugar pyrophosphorylase (USPase) and UDP-N-acety lglucosamine pyrophosphorylase (UAGPase), which can be discriminated both by differences in accepted substrate range and amino acid sequences. LÄS MER

  5. 4. The Biophysics of Na+,K+-ATPase in neuronal health and disease

    Författare :Evgeny E. Akkuratov; Hjalmar Brismar; Anita Aperia; Stefan Wennmalm; Poul Nissen; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Na ; K -ATPase; NMDA receptor; ouabain; phosphoproteome; oligomerization; rapid-onset dystonia-parkinsonism; Biologisk fysik; Biological Physics;

    Sammanfattning : Na+,K+-ATPase is one of the most important proteins in the mammalian cell. It creates sodium and potassium gradients which are fundamental for the membrane potential and sodium-dependent secondary active transport. LÄS MER

  7. 5. Multifaceted adaptation in adherence by the gastric pathogen Helicobacter pylori

    Författare :Yevgen Chernov; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; H. pylori; BabA; oligomerization; Leb; recombination; mutation; adherence; pH-sensitive; pH-resistant;

    Sammanfattning : .... LÄS MER