Sökning: "phosphoproteome"
Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet phosphoproteome.
1. The Biophysics of Na+,K+-ATPase in neuronal health and disease
Sammanfattning : Na+,K+-ATPase is one of the most important proteins in the mammalian cell. It creates sodium and potassium gradients which are fundamental for the membrane potential and sodium-dependent secondary active transport. LÄS MER
2. Phosphoproteomics to tackle brain disorders : Insight into the murine brain phosphoproteome
Sammanfattning : Brain disorders affect the normal functionality of the brain causing inability in controlling certain behaviours. In the last two decades, despite the technological advancement, many biological questions concerning brain mechanisms and neural networks remain still unclear. LÄS MER
3. Characterizing cancer cell signaling at the protein level : from targeted to proteome and phosphoproteome‐wide analyses
Sammanfattning : Proteins are the effectors of cellular functions and the constituting elements of cellular signaling cascades. The ability to analyze the abundances and the dynamics of proteins is central to dissect cellular signaling and its effects on cell physiology. LÄS MER
4. Genes and proteins controlled by cGMP-PKG during retinal degeneration
Sammanfattning : prevalence was reported as 1:3000-4000 worldwide, making it the main reason for blindness in the working population in industrial countries. The mutations of over 70 genes have been related to this genetic disorder, and there is generally no effective treatment, except for gene therapy for the RPE65 mutations. LÄS MER
5. Apoptosis-related mechanisms in the immature brain after hypoxia-ischemia
Sammanfattning : Aims: To characterize the activation of caspases-3 and extracellular signal-regulated kinase (ERK) in the neonatal brain after hypoxia-ischemia (HI) injury and evaluate the neuroprotective effect of X-linked inhibitor of apoptosis (XIAP) protein, erythropoietin (EPO) and the non-erythropoietic derivative asialoEPO. Methods: Seven-day-old rats or 9-day-old mice were subjected to HI. LÄS MER