Sökning: "cGMP-dependent protein kinase II"

Hittade 4 avhandlingar innehållade orden cGMP-dependent protein kinase II.

  1. 1. Screening for Candidate Brain Tumor Genes : Identifying Genes that Cooperate with Platelet-Derived Growth Factor in Glioma Development and Progression

    Författare :Fredrik Johansson; Bengt Westermark; Leif Carlsson; Uppsala universitet; []
    Nyckelord :Pathology; PDGF; insertional mutagenesis; retroviral tagging; common insertion site; glioma; expression; cGMP-dependent protein kinase II; Patologi;

    Sammanfattning : Malignant primary brain tumors, gliomas, often overexpress both platelet-derived growth factor (PDGF) ligands and receptors providing an autocrine and/or paracrine boost to tumor growth. Glioblastoma multiforme (GBM) is the most frequent glioma. Its aggressive and infiltrative growth renders it extremely difficult to treat. LÄS MER

  3. 2. Cyclic nucleotide signalling in Alzheimer's disease postmortem brain

    Författare :Willy Lokwa Bonkale; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of this study was to determine the nature and significance of altered guanylyl cyclase (GC) and adenylyl cyclase (AC) signalling in Alzheimer's disease (AD) postmortem brain. Paper I describes a study of particulate and soluble GC activities in postmortem temporal cortex from a series of AD and matched control subjects. LÄS MER

  4. 3. The role of red blood cells in cardiac and endothelial dysfunction in cardiometabolic disease

    Författare :Tong Jiao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Cardiometabolic disease, which includes the combination of cardiovascular disease, especially coronary artery disease and type 2 diabetes (T2D), is a major health problem and cause of mortality worldwide. ST-elevation myocardial infarction (STEMI) occurs when coronary arteries are occluded and is regarded as a life-threatening disorder. LÄS MER

  5. 4. The potential role of retinal cGMP-interaction partners within the degeneration mechanism causing Retinitis Pigmentosa

    Författare :Michel Rasmussen; Lund Oftalmologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Retinitis Pigmentosa; Photoreceptors; cGMP; cGMP-interactors; retinal degeneration; neuroprotection;

    Sammanfattning : The eye disease Retinitis Pigmentosa (RP) represents a heterogeneous group of inherited retinal dystrophies, and it has been estimated that 1 in 3000 to 7000 people worldwide has the disease. The symptoms of RP are photoreceptor degeneration that leads to night blindness, followed by a decline in peripheral and central vision, and potential blindness. LÄS MER