Sökning: "Mesenchymal stem cell"

Visar resultat 11 - 15 av 120 avhandlingar innehållade orden Mesenchymal stem cell.

  1. 11. Regulation of cell polarity and invasion by TGF-β and BMP signaling

    Författare :Mahsa Shahidi Dadras; Aristidis Moustakas; Petra Knaus; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cancer; cancer stem cells; invasion; metastasis; polarity; TGF-β signaling.;

    Sammanfattning : Transforming growth factor β (TGF-β) and bone morphogenetic protein (BMP) signaling pathways are involved in many physiological processes during embryonic and adult life. TGF-β promotes epithelial to mesenchymal transition (EMT). We identified a gene target of TGF-β signaling, encoding the salt-inducible kinase 1 (SIK1). LÄS MER

  3. 12. Regulation of cell differentiation and invasion by members of the TGFß family

    Författare :Kalliopi Tzavlaki; Aristidis Moustakas; Carl-Henrik Heldin; Laia Caja; Staffan Johansson; Gareth Inman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGFβ; BMP; LKB1; signal transduction; cancer; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) signaling pathways are important in embryonic development and tissue homeostasis, but also have complex roles in the context of cancer. TGFβ promotes epithelial to mesenchymal transition (EMT) a physiological developmental process, often hijacked in different types of cancer, eventually leading to cancer cell invasion and metastasis. LÄS MER

  4. 13. Development and optimization of a 3D in vitro model for osteogenic biomaterial evaluation

    Författare :Luis Oliveros Anerillas; Peyman Kelk; Paul J. Kingham; Mikko Lammi; Jöns Hilborn; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; angiogenesis; biomaterial; bone marrow mesenchymal stem cells; bone regeneration; hydrogel; osteoinduction; osteogenesis; scaffold; type I collagen; 3D culture; biology; biologi; biomedical laboratory science; biomedicinsk laboratorievetenskap; Medical Cell Biology; medicinsk cellbiologi;

    Sammanfattning : Despite the innate regenerative capabilities of bone tissue, self-repair is impaired when an injury exceeds the critical size threshold because of trauma, congenital, or pathological conditions. Autologous transplantation is the gold standard to reconstruct large bone defects. LÄS MER

  5. 14. Stem cell signatures in glioma

    Författare :Xiaobing He; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gliomas are the most common tumors of the central nervous system in adults. Glioblastoma, the most aggressive form, has a median survival of 15 months regardless of the standard treatment with surgery and temozolomide-based radiochemotherapy. Therefore, it is imperative to improve treatment options for patients with glioblastoma. LÄS MER

  7. 15. Schwann cells and mesenchymal stem cells as promoter of peripheral nerve regeneration

    Författare :Maria Cristina Mantovani; Mikael Wiberg; Giorgio Terenghi; Susan Shawcross; Lev Novikov; Liudmila Novikova; John W Haycock; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peripheral nerve regeneration; Schwann cell; adult stem cell; myelin; senescence;

    Sammanfattning : The transplantation of primary Schwann cells (SC) has been shown to improve nerve regeneration. However, to monitor the survival of transplanted cells within the host, a stable labelling method is required. LÄS MER