Sökning: "Paul J. Kingham"

Hittade 4 avhandlingar innehållade orden Paul J. Kingham.

  1. 1. Cell therapy for denervated tissue

    Författare :Roine El-Habta; Ludvig J. Backman; Paul J. Kingham; Patrik Danielson; António Salgado; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose tissue-derived stem cell; cell therapy; denervation; differentiation; myoblast; peripheral nerve injury; proliferation; regeneration; skeletal muscle; stromal vascular fraction; survival; tendon; cellforskning; cell research; Medical Cell Biology; medicinsk cellbiologi;

    Sammanfattning : Background: Peripheral nerve injury results in denervation of tendons and muscles. The biology of denervated muscle has been well studied but little is known about the associated tendons. LÄS MER

  3. 2. Transplantation of mesenchymal stem cells and injections of microRNA as therapeutics for nervous system repair

    Författare :Mallappa K. Kolar; Lev N. Novikov; Paul J. Kingham; Mikael Wiberg; Elisabet Åkesson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spinal cord injury; peripheral nerve injury; mesenchymal stem cells; regeneration; neurotrophic factor; angiogenic factor;

    Sammanfattning : Traumatic injuries to the spinal cord (SCI) and peripheral nerve (PNI) affect several thousand people worldwide every year. At present, there is no effective treatment for SCI and despite continuous improvements in microsurgical reconstructive techniques for PNI, many patients are still left with permanent, devastating neurological dysfunction. LÄS MER

  4. 3. Optimizing stem cells for reconstructive surgery

    Författare :Anne Therese Lauvrud; Paul J. Kingham; Rebecca Wiberg; Peyman Kelk; Maria Brohlin; Susanna Kauhanen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipose tissue-derived stem cells; liposuction; oncological safety; xenofree growth medium; Human Anatomy; anatomi;

    Sammanfattning : Fat grafting has become an established method in plastic surgery for treating soft tissue defects. The results for survival of the fat being transplanted is unpredictable and supplementation of the graft with the Stromal Vascular Fraction (SVF) or cultures Adipose tissue-derived stem cells (ASCs) can enhance graft viability. LÄS MER

  5. 4. Development and optimization of a 3D in vitro model for osteogenic biomaterial evaluation

    Författare :Luis Oliveros Anerillas; Peyman Kelk; Paul J. Kingham; Mikko Lammi; Jöns Hilborn; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; angiogenesis; biomaterial; bone marrow mesenchymal stem cells; bone regeneration; hydrogel; osteoinduction; osteogenesis; scaffold; type I collagen; 3D culture; biology; biologi; biomedical laboratory science; biomedicinsk laboratorievetenskap; Medical Cell Biology; medicinsk cellbiologi;

    Sammanfattning : Despite the innate regenerative capabilities of bone tissue, self-repair is impaired when an injury exceeds the critical size threshold because of trauma, congenital, or pathological conditions. Autologous transplantation is the gold standard to reconstruct large bone defects. LÄS MER