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Visar resultat 21 - 25 av 31 avhandlingar som matchar ovanstående sökkriterier.

1. 21. A high-throughput pathology approach for further insight into the role of RBM3 as a biomarker of prognosis and chemotherapy response in human cancer

   Författare :Liv Ben Dror; Tumörmikromiljö; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Cancer incidence is increasing and it is the number one cause of death worldwide. Cancer is a highly heterogeneous disease and there is a great need for new early diagnostic, prognostic and treatment predictive biomarkers in order to improve patient outcomes. LÄS MER

3. 22. On the application and validation of multiplexed affinity assays

   Författare :Tea Dodig-Crnković; Jochen M. Schwenk; Mun-Gwan Hong; Peter Nilsson; Norman Leigh Anderson; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affinity proteomics; Antibody; Autoantibody; Multiplexed assays; Protein microarray; Plasma proteins; Suspension bead array; Bioteknologi; Biotechnology;

   Sammanfattning : Proteins are essential macromolecules that carry out complex functions in human cells, tissues, and organs. They regulate a diverse set of biological processes and protect against pathogens. However, dysregulation or malformation of proteins can cause disease. LÄS MER

4. 23. Women, smoking and myocardial infarction

   Författare :Ellis Janzon; Kardiovaskulär forskning - epidemiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epidemiology; Medicine human and vertebrates ; Smoking cessation; Smoking; risk; Prevention; Trends; Myocardial infarction; Women; epidemiologi; Folkhälsa; Public health; Medicin människa och djur ; Blood pressure; Women;

   Sammanfattning : The aim of this thesis has been to explore factors associated with smoking and smoking cessation in women and the relation between smoking and incidence of myocardial infarction (MI). The time trends in incidence of MI 1986-2002 in the city of Malmö (pop. 250.000) were explored. LÄS MER

5. 24. bHLH transcription factors in differentiating neuroblastoma cells

   Författare :Anna Grynfeld; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bHLH; Neuroblastoma; HES-1; HASH-1; N-Myc; differentiation; Mad; Medicine human and vertebrates ; Medicin människa och djur ;

   Sammanfattning : Neuroblastoma is a tumor of the sympathetic nervous system, and arises during early childhood. The tumor is highly heterogeneous and evidence, such as expression of genes normally only expressed during embryonic and fetal stages, suggests that the tumor is of embryonic origin and that the tumor arises as a consequence of perturbed differentiation during the development of the sympathetic nervous system. LÄS MER

7. 25. Interactions of Anticancer Active Platinum(II) Complexes with DNA

   Författare :Johan Kjellström; Bröstcancer-genetik; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Inorganic chemistry; polyelectrolyte; medium effects; salt dependence; DSC; CD; HPLC; oligonucleotide; hairpin; DNA; anticancer active platinum II compounds; kinetics; mechanism; Oorganisk kemi; Cytology; oncology; cancerology; Cytologi; onkologi; cancer;

   Sammanfattning : The kinetics and mechanism for interactions of the anticancer active platinum(II) complexes cis-[PtCl2(NH3)2)], cis-[PtCl2(NH3)(c-C6H11NH2)], and trans-[PtCl2-(NH3)(quinoline)] with DNA have been studied using a combination of HPLC, circular dichroism (CD), UV/vis spectroscopy, and differential scanning calorimetry (DSC). Reactions of the monoaqua forms (charge = +1) of these complexes with single-stranded DNA oligonucleotides, typically between 13-17 bases long, were found to depend on i) the composition of the reaction medium, ii) the exact nature and location of the platination target, and iii) on the DNA structure. LÄS MER