Sökning: "HASH-1"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet HASH-1.

  1. 1. Regulation and functions of basic helix-loop-helix transcription factors in neuroblastoma cells

    Författare :Paula Persson; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; Id; Olf EBF; ubiquilin-1; HASH-1; bHLH; Neuroblastoma; neuronal differentiation; cancer; onkologi; cancerology; Cytologi;

    Sammanfattning : Neuroblastoma is a childhood tumor derived from primordial neural crest cells. The tumor cells exhibit a phenotype similar to that of developing neuroblasts, which indicates that the tumor arises due to perturbed differentiation of the sympathetic nervous system. LÄS MER

  3. 2. bHLH transcription factors in differentiating neuroblastoma cells

    Författare :Anna Grynfeld; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bHLH; Neuroblastoma; HES-1; HASH-1; N-Myc; differentiation; Mad; Medicine human and vertebrates ; Medicin människa och djur ;

    Sammanfattning : Neuroblastoma is a tumor of the sympathetic nervous system, and arises during early childhood. The tumor is highly heterogeneous and evidence, such as expression of genes normally only expressed during embryonic and fetal stages, suggests that the tumor is of embryonic origin and that the tumor arises as a consequence of perturbed differentiation during the development of the sympathetic nervous system. LÄS MER

  4. 3. Notch Signaling in Human Neuroblastoma Cells

    Författare :Marie Stockhausen; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Hes-1; Medicin människa och djur ; Medicine human and vertebrates ; hypoxia; TGF-alpha; EGFR; ERK1 2; Ras MAPK; differentiation; valproic acid; ubiquilin-1; neuroblastoma; Hash-1; Cytologi; onkologi; cancer; cancerology; Cytology; Notch;

    Sammanfattning : Neuroblastoma is a childhood tumor derived from the sympathetic nervous system (SNS). It is believed that the tumors arise from cells halted in their differentiation and due to their immature phenotype; they express proteins normally only detected during embryogenesis. One such protein is Hash-1, which is required for formation of the SNS. LÄS MER

  5. 4. Regulation of the GAP-43, C-SRC, HASH-1 and ID genes during neuronal differentiation of neuroblastoma cells

    Författare :Eva Örtoft; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  7. 5. Transcriptional regulation in neuroblastoma cells under normoxic and hypoxic conditions

    Författare :Annika Jögi; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; cancerology; Cytologi; onkologi; cancer; Cytology; HIF-2; HIF-1; hypoxia; Id; HES-1; bHLH; Neuroblastoma; neuronal differentiation;

    Sammanfattning : The childhood malignancy neuroblastoma develops from early cells of the sympathetic nervous system (SNS), and the tumors often produce catecholamines. Neuroblastoma cells retain several characteristics of immature sympathetic cells including the expression of a number of transcription factors normally expressed during embryogenesis. LÄS MER