Sökning: "Radiochemistry"
Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet Radiochemistry.
1. Development of Palladium-Promoted 11C/12C-Carbonylations and Radiosynthesis of Amyloid PET Ligands
Sammanfattning : In the first part of this thesis, palladium(0)-catalyzed and -mediated carbonylations are discussed. Paper I describes a new method for the safe, efficient use of a solid carbon monoxide source in the synthesis of primary and secondary benzamides. LÄS MER
2. Exploring Palladium-Mediated 11C/12C-Carbonylation Reactions : PET Tracer Development Targeting the Vesicular Acetylcholine Transporter
Sammanfattning : The work presented herein describes the utilization and exploration of palladium-mediated incorporations of carbon monoxide and/or [11C]carbon monoxide into compounds and structural motifs with biological relevance.The first part of the thesis describes the design, synthesis and 11C-labeling of prospective PET tracers for the vesicular acetylcholine transporter (VAChT), a target affected in several neurodegenerative diseases. LÄS MER
3. Primordial radionuclides in pit lakes in Sweden
Sammanfattning : In Sweden, there are many pit lakes, originating from limestone quarries and metal mines, with unknown status in regard to the activity concentration of radionuclides. Such knowledge is generally available only for pit lakes from uranium mining activi-ties. LÄS MER
4. Method development for [11C]carbon monoxide radiochemistry
Sammanfattning : Positron emission tomography (PET) is a non-invasive molecular imaging technique that has found extensive utility in biomedical research and in drug development. A fundamental pre-requisite for PET is the tracer, which is a biologically relevant molecule, labeled with a short-lived radionuclide. LÄS MER
5. Methodological advancements in microfluidic and carbonylation PET radiochemistry
Sammanfattning : Along with the progress of PET as a powerful imaging tool in medicine, there has been increasing demand for new labeling methods. The main aim of this PhD dissertation was to develop novel labeling methodologies using the positron emitter carbon-11. LÄS MER