Sökning: "Fredrik Lehmann"

Hittade 4 avhandlingar innehållade orden Fredrik Lehmann.

  1. 1. Synthesis and Structure-Activity Relationship. Studies of Non-Peptidic Urotensin II Receptor Agonists

    Författare :Fredrik Lehmann; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  3. 2. Human Interactions on Online Social Media : Collecting and Analyzing Social Interaction Networks

    Författare :Fredrik Erlandsson; Johnson Henric; Martin Boldt; Piotr Bródka; S. Felix Wu; Sune Lehmann; Blekinge Tekniska Högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Social Media; Social Networks; Crawling; Complex Networks; Information Cascade; Seed Selection; Privacy;

    Sammanfattning : Online social media, such as Facebook, Twitter, and LinkedIn, provides users with services that enable them to interact both globally and instantly. The nature of social media interactions follows a constantly growing pattern that requires selection mechanisms to find and analyze interesting data. LÄS MER

  4. 3. A Chemical Approach Toward the Therapeutic Optimization of Cytotoxic Bioconjugates

    Författare :Rafael Hartmann; Luke R. Odell; Fredrik Lehmann; Mats Larhed; Dario Neri; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemotherapy; antibody-drug conjugates; organic synthesis; bioorganic chemistry; synthetic method development; analytical method development; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi; Medicinal Chemistry; Läkemedelskemi; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi;

    Sammanfattning : The delivery of cytotoxicity to specific cells was recognized to be the key to the effective, chemical treatment of infectious and neoplastic diseases well over a century ago. In the context of oncology, the primary therapeutic challenge is the distinction between healthy and pathological cells despite their pronounced pheno- and genotypic similarity. LÄS MER

  5. 4. Development and evaluation of analytical techniques for antibodies and antibody-drug conjugates : From verification of conjugation to stability testing

    Författare :Malin Källsten; Jonas Bergquist; Fredrik Lehmann; Sara Lind; Lucia Kovac; Alain Beck; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibody-drug conjugates; drug-to-antibody ratio; monoclonal antibody; mass spectrometry; hydrophobic interaction chromatography; sample preparation; aggregation; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Antibody-drug conjugates (ADCs) are becoming increasingly important in oncology. ADCs are inherently heterogeneous analytes. For a successful drug candidate to go through to the clinic, extensive characterization and evaluation of the constructs are necessary. LÄS MER