Sökning: "leukemic stem cells"

Visar resultat 1 - 5 av 48 avhandlingar innehållade orden leukemic stem cells.

  1. 1. Identification and Characterization of Stem Cells in Preleukemia and Leukemia

    Författare :Lars Nilsson; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; extracellulära vätskor; Hematologi; Philadelphia chromosome; acute lymphoblastic leukemia; polycytemia vera; 5q- syndrome; myelodysplastic syndromes; self-renewal; preleukemia; Hematopoietic stem cells; leukemic stem cells; extracellular fluids;

    Sammanfattning : Hematopoietic stem cells (HSCs) are responsible for the daily and life long production of large numbers of mature blood cells through highly regulated self-renewal and multilineage capabilities. Leukemias on the other hand, are characterized by a clonal, dysregulated, lineage skewed proliferation and impaired differentiation as the result of multiple accumulated genetic events. LÄS MER

  2. 2. Targeting residual malignant cells in myeloid leukemia

    Författare :Malin Nilsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute myeloid leukemia; chronic myeloid leukemia; histamine dihydrochloride; hydroxyurea; leukemic stem cells;

    Sammanfattning : Malignant cells persisting during treatment prevent cure in many patients with myeloid leukemia. In acute myeloid leukemia (AML), the failure to eradicate the leukemic clone during conventional chemotherapy is associated with leukemic relapse, mostly with dismal survival outcome. LÄS MER

  3. 3. Regulation of normal and cancer cells as a base for cell cycle-targeted therapy

    Författare :Regina Miftakhova; Malmö Experimentell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell cycle regulation; cyclin A1; stem cells; stem cell niche; epigenetics; cancer;

    Sammanfattning : The majority of current treatments used for treatment of prostate cancer (PCa) and leukemia are often limited to a narrow subsets of treated patients. As such, there still remains a significant scope for gaining deeper understanding of molecular mechanisms underlying cancer metastasis for improvement of targeted treatment. LÄS MER

  4. 4. Response mechanisms of normal hematopoietic cells and leukemic cells to genotoxic agents and novel therapeutic strategies

    Författare :Andreas Hedblom; Malmö Experimentell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic stem cells; genotoxic damage; cell cycle; leukemia; heme oxygenase; differentiation;

    Sammanfattning : Hematopoiesis is initiated by a rare population of hematopoietic stem cells (HSC) in the bone marrow (BM). HSCs give rise to red blood cells and white blood cells of myeloid and lymphoid lineages. LÄS MER

  5. 5. Stem and progenitor cell involvement in acute lymphoblastic leukemia

    Författare :Anders Castor; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; Haematology; Cytology; oncology; cancerology; Cytologi; onkologi; Medicin människa och djur ; Medicine human and vertebrates ; ETV6-RUNX1; BCR-ABL1; stem cells; Acute lymphoblastic leukemia; extracellular fluids; Hematologi; extracellulära vätskor;

    Sammanfattning : Leukemic stem cells (LSCs) share the capacity of self renewal and extensive proliferation with normal hematopoietic stem cells (HSCs), and are therefore obvious targets for therapy. As such, they need to be identified and characterized in order to elucidate what drives them, and what separates them from their normal counterparts. LÄS MER