Sökning: "CTLA4"

Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet CTLA4.

  1. 1. The genetic complexity of celiac disease. Gene variants linked and associated to an inflammatory autoimmune disorder

    Författare :Åsa Torinsson Naluai; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Celiac disease; genome-wide scan; linkage; association; complex disease; autoimmune; CTLA4; 5q31-33; polymorphism;

    Sammanfattning : .... LÄS MER

  2. 2. Biologics in Staphylococcus aureus arthritis

    Författare :Abukar Ali; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Staphylococcus aureus; CTLA4-Ig; IL-1 Ra; anti-TNF therapy; mouse; septic arthritis;

    Sammanfattning : The emergence of new type of drugs known as biologics has led to rapid disease improvements in many autoimmune arthritic patients. Nevertheless, most of these biologics are immunomodulators that may consequently increase the susceptibility of patients towards infections, such as septic arthritis. LÄS MER

  3. 3. A sub-phenotype approach to dissect the genetic control of murine type 1 diabetes

    Författare :Marie-Louise Bergman; Leif Andersson; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes (T1D). The disease in the NOD mouse is polygenic and multifactorial and so far at least 20 insulin dependent diabetes (Idd) susceptibility loci have been identified. However, no etiological mutations have been definitely ascribed to the Idd loci. LÄS MER

  4. 4. Co-stimulatory molecules : genes to protein in autoimmune and inflammatory disorders

    Författare :Priya Sakthivel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Co‐stimulatory molecules are antigen‐independent generators of secondary signals which aid in maintaining the homeostasis of the immune system. The most extensively studied co‐stimulatory pathway is CD28/CTLA‐4, expressed on the T cells, interacting with CD80/CD86, expressed on the antigen presenting cells (APC). LÄS MER

  5. 5. Heritable modulators of the multiple sclerosis phenotype

    Författare :Thomas Masterman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Studies of families in which more than one case of multiple sclerosis (MS) occurs have demonstrated that shared genetic and/or environmental factors appear to modify clinical features of the disease, including rate of progression and disease course. We undertook in the present project to determine to what extent selected genetic factors constitute heritable determinants of the MS phenotype. LÄS MER