Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet CTLA4.
1. The genetic complexity of celiac disease. Gene variants linked and associated to an inflammatory autoimmune disorder
Sammanfattning : .... LÄS MER
Sammanfattning : The emergence of new type of drugs known as biologics has led to rapid disease improvements in many autoimmune arthritic patients. Nevertheless, most of these biologics are immunomodulators that may consequently increase the susceptibility of patients towards infections, such as septic arthritis. LÄS MER
Sammanfattning : The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes (T1D). The disease in the NOD mouse is polygenic and multifactorial and so far at least 20 insulin dependent diabetes (Idd) susceptibility loci have been identified. However, no etiological mutations have been definitely ascribed to the Idd loci. LÄS MER
Sammanfattning : Co‐stimulatory molecules are antigen‐independent generators of secondary signals which aid in maintaining the homeostasis of the immune system. The most extensively studied co‐stimulatory pathway is CD28/CTLA‐4, expressed on the T cells, interacting with CD80/CD86, expressed on the antigen presenting cells (APC). LÄS MER
Sammanfattning : Studies of families in which more than one case of multiple sclerosis (MS) occurs have demonstrated that shared genetic and/or environmental factors appear to modify clinical features of the disease, including rate of progression and disease course. We undertook in the present project to determine to what extent selected genetic factors constitute heritable determinants of the MS phenotype. LÄS MER