Sökning: "Fluoxetine"

Visar resultat 6 - 10 av 34 avhandlingar innehållade ordet Fluoxetine.

1. 6. Galanin : a modulator of serotonin neurotransmission : relevance for depression

   Författare :Haleh Razani; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :galanin; 5-HT1A receptors; 5-HT; 8-OH-DPAT; fluoxetine; robalzotan; passive avoidance; microdialysis; mRNA; KD values; Bmax values; depression;

   Sammanfattning : Galanin is widely distributed throughout the central nervous system with multiple and diverse biological roles. In the rat, galanin-like immunoreactivity is expressed in a population of5-hydroxytryptamine (5-HT, serotonin) neurons in the dorsal raphe (DR) with extensive projections to the forebrain areas e.g., hippocampus. LÄS MER

3. 7. Spinal motoneurones and the bulbospinal serotonininergic system in aged rats with behavioral deficits

   Författare :Hans Johnson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :aging; behavior; immunohistochemistry; in situ hybridisation; motoneuron; CGRP; axotorny; GAP-43; neurotrophin receptors; degeneration; axon dystrophy; 5HT TRH; SP; 5HLkA; AADC; serotonintransporter protein; fluoxetine; L-5-HTP;

   Sammanfattning : The expression of neuropeptides, growth-related proteins and neurotrophin receptors were studied in motoneurons of young adult rats and in aged rats with symptoms of neuromuscular incapacities. Also studied were aging-related changes in the descending serotoninergic (5HT) bulbospinal system which constitutes a major afferent pathway to spinal motoneurons. LÄS MER

4. 8. Development of LC-MS/MS Methods for the Analysis of Chiral and Achiral Pharmaceuticals and Metabolites in Aqueous Environmental Matrices

   Författare :Victoria K.H. Barclay; Curt Pettersson; Monika Johansson; Niklas Tyrefors; Mohamed Abdel-Rehim; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environmental water matrices; chiral separation; LC-MS MS; trace analysis; method development; active pharmaceutical ingredients; metabolites; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

   Sammanfattning : This thesis describes the development of liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for the trace analysis of active pharmaceutical ingredients (APIs) and their metabolites in aqueous environmental matrices. The research was focused on the development of chiral LC-MS/MS methods for the analysis of fluoxetine and metoprolol, as well as their chiral metabolites in environmental water samples. LÄS MER

5. 9. Clinical and Pharmacological Aspects of Selective Serotonin Reuptake Inhibitors in the Treatment of Depression in Old Age

   Författare :Jöns Lundmark; Finn Bengtsson; Leif Lindström; Linköpings universitet; []
   Nyckelord :Serum concentrations; cerebrospinal fluid; pharmacokinetics; selective serotonin reuptake inhibitors; therapeutic drug monitoring; elderly; depression; pharmaceutical economics; MEDICINE; MEDICIN;

   Sammanfattning : Objective: The aim of the present thesis is to examine the pharmacokinetic and biochemical effects of the selective serotonin reuptake inhibitors (SSRIs) in the elderly.Background: Symptoms of depression are found in up to 15% of the elderly and the prevalence of major depression is reported to be about 3%. LÄS MER

7. 10. Cell damage and tissue repair in the central nervous system : electron mi[c]roscopy study of neuronal death and cell replacement

   Författare :Benita Andersson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Ischemia; cell death; repair; stem cells; neurogenesis; EM; MRI;

   Sammanfattning : The central nervous system is vulnerable to various insults and particularly to ischemia. To mimic ischemia, a photochemical or compression lesion was induced in the right sensory motor cortex of rat brains. LÄS MER