Sökning: "degeneration"

Visar resultat 1 - 5 av 386 avhandlingar innehållade ordet degeneration.

1. 1. The Vicissitudes of Corruption : Degeneration - transgression - jouissance

   Författare :Thomas Taro Lennerfors; Claes Gustafsson; Thomas Polesie; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Industrial organisation; administration and economics; Industriell organisation; administration och ekonomi;

   Sammanfattning : In a time when corruption is receiving increasing media coverage and when many claim to wage a war on corruption, this book brings up the need for a problematisation and an increased understanding of the different manifestations – the vicissitudes – of corruption and also what measures are taken against it. The book advances the claim that corruption is tightly related to modernity and particularly to a transgression of the public / private dichotomy. LÄS MER

3. 2. Functional consequences of dopaminergic degeneration : Clinical and experimental studies using a novel stabilizer of dopaminergic systems

   Författare :Anna Ekesbo; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; positron emission tomography; 6-OHDA; MPTP; dyskinesia; dopaminergic degeneration; - -OSU6162; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

   Sammanfattning : Since the introduction of levodopa for the treatment of Parkinson's disease (PD) 30 yearsago, the emergence of motor complications, such as levodopa-induced dyskinesias (LID), hasbeen a major clinical problem in advanced stages of the disease. Clinical and preclinical studieshave revealed a number of functional changes in the dopaminergic system that may be ofimportance for the emergence of LIDs. LÄS MER

4. 3. rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration

   Författare :Poonam Ahuja Jensen; Allmänmedicin och samhällsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oftalmologi; Ophtalmology; retinal degeneration; Survival factors; metalloproteases;

   Sammanfattning : The thesis is focused on an attempt to delay photoreceptor cell death in the rd1 mouse using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse model displays a retina degeneration which starts around day 10 with rod photoreceptor cell death. LÄS MER

5. 4. Molecular Mechanisms of Frontotemporal Lobar Degeneration

   Författare :Lena Skoglund; Anna Glaser; Martin Ingelsson; Lars Lannfelt; Stuart Pickering-Brown; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Frontotemporal lobar degeneration; Frontotemporal dementia; Tau; Progranulin; Alternative splicing; Nonsense-mediated decay; Haploinsufficiency;

   Sammanfattning : The aim of this thesis was to identify genetic factors involved in frontotemporal lobar degeneration (FTLD), a neurodegenerative disorder clinically characterised by a progressive change in personality, behaviour and language. FTLD is a genetically complex disorder and a positive family history is found in up to 40% of the cases. LÄS MER

7. 5. Cell Therapy in lntervertebral Disc Degeneration

   Författare :Papadimitriou Nicolaos; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Low back pain; Mesenchymal stromal cell; Intervertebral disc; Intervertebral disc degeneration; Degenerative disc disease; Cell therapy;

   Sammanfattning : Background: Chronic low back pain (LBP) is the leading cause of disability worldwide. Intervertebral disc degeneration (IDD) is central in the pathogenesis. The injection of bone marrow-derived mesenchymal stromal cells (BM-MSCs) into degenerate intervertebral discs (IVDs) has been proposed as an alternative therapy. LÄS MER