Sökning: "selective serotonin reuptake inhibitors"

Visar resultat 1 - 5 av 42 avhandlingar innehållade orden selective serotonin reuptake inhibitors.

1. 1. On the efficacy and prescription of serotonin reuptake inhibitors

   Författare :Alexander Lisinski; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antidepressants; antidepressive agents; major depressive disorder; selective serotonin reuptake inhibitor; serotonin and noradrenaline reuptake inhibitor; tricyclic antidepressant;

   Sammanfattning : This thesis addresses several controversial issues regarding commonly used antidepressants, including selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs), and tricyclic antidepressants (TCAs). To this end, patient-level data from 28 placebo-controlled trials on SSRIs and 13 corresponding trials on the SNRI duloxetine, were requested and obtained. LÄS MER

3. 2. Importance of serotonin-related candidate genes for human behaviour

   Författare :Jonas Melke; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serotonin; genetics; polymorphism; association study; personality; panic disorder; premenstrual dysphoria; serotonin receptor; serotonin transporter;

   Sammanfattning : Family and twin studies have been consistent in demonstrating that genetic factors are involved in the etiology of most major psychiatric disorders, as well as in various normal personality traits. Mostly due to the efficacy of serotonin-acting drugs, such as selective serotonin reuptake inhibitors (SSRI) and tricyclic antidepressants (TCA), the neurotransmitter serotonin has been implicated in a variety of common psychiatric disorders, including depression, a spectrum of anxiety disorders, and premenstrual dysphoria; moreover, some studies have suggested that also personality is influenced by serotonin. LÄS MER

4. 3. On the Effects of Serotonin Reuptake Inhibitors in Major Depression

   Författare :Fredrik Hieronymus; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antidepressants; antidepressive agents; depression; major depressive disorder; selective serotonin reuptake inhibitor; SNRI; SSRI;

   Sammanfattning : This thesis focuses on the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) and how these are reflected by the Hamilton Depression Rating Scale (HDRS). To this end, we have assembled a large data set of placebo-controlled SSRI trials in major depression, and used this for a series of post-hoc patient-level analyses. LÄS MER

5. 4. Behavioural outcomes of treatment with selective serotonin reuptake inhibitors

   Författare :Tyra Lagerberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Mood and anxiety disorders are some of the biggest contributors to morbidity worldwide, and may be lethal. Appropriate treatment is therefore paramount. LÄS MER

7. 5. Clinical and Pharmacological Aspects of Selective Serotonin Reuptake Inhibitors in the Treatment of Depression in Old Age

   Författare :Jöns Lundmark; Finn Bengtsson; Leif Lindström; Linköpings universitet; []
   Nyckelord :Serum concentrations; cerebrospinal fluid; pharmacokinetics; selective serotonin reuptake inhibitors; therapeutic drug monitoring; elderly; depression; pharmaceutical economics; MEDICINE; MEDICIN;

   Sammanfattning : Objective: The aim of the present thesis is to examine the pharmacokinetic and biochemical effects of the selective serotonin reuptake inhibitors (SSRIs) in the elderly.Background: Symptoms of depression are found in up to 15% of the elderly and the prevalence of major depression is reported to be about 3%. LÄS MER