Sökning: "NS3 protease inhibitors"

Visar resultat 1 - 5 av 26 avhandlingar innehållade orden NS3 protease inhibitors.

  1. 1. Design and Synthesis of Serine and Aspartic Protease Inhibitors

    Detta är en avhandling från Institutionen för fysik, kemi och biologi

    Författare :Fredrik Wångsell; Ingemar Kvarnström; Olle Karlsson; [2006]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; metathesis; HCV; NS3; protease; proline isosteres; inhibitor; aspartic protease inhibitors; hydroxyethylene; NATURAL SCIENCES Chemistry Organic chemistry Organic synthesis; NATURVETENSKAP Kemi Organisk kemi Organisk syntes;

    Sammanfattning : This thesis describes the design and synthesis of compounds that areintended to inhibit serine and aspartic proteases. The first part of the text deals with preparation of inhibitors of the hepatitis C virus (HCV) NS3 serine protease. Hepatitis C is predominantly a chronic disease that afflicts about 170 million people worldwide. LÄS MER

  2. 2. Peptidomimetic Enzyme Inhibitors Targeting M. tuberculosis Ribonucleotide Reductase and Hepatitis C Virus NS3 Protease

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Johanna Nurbo; Anders Hallberg; Anders Karlén; Anja Sandström; Per Arvidsson; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzyme inhibitor; peptidomimetics; structure-activity relationship; tuberculosis; ribonucleotide reductase; hepatitis C virus; NS3 protease; PHARMACY Pharmaceutical chemistry; FARMACI Farmaceutisk kemi; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : This thesis focuses on the design and synthesis of inhibitors targeting Mycobacterium tuberculosis ribonucleotide reductase (RNR) and hepatitis C virus (HCV) NS3 protease; enzymes that have been identified as potential drug targets for the treatment of tuberculosis and hepatitis C, respectively. Small peptides have been recognized as inhibitors of these enzymes. LÄS MER

  3. 3. Design and Synthesis of Aspartic and Serine Protease Inhibitors Targeting the BACE-1 and the HCV NS3 Protease

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Fredrik Wångsell; Mats Larhed; Jari Yli-Kauhaluoma; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; BACE-1; transition state mimetic; tertiary hydroxyl group; hydroxyethylene; statine; hydroxyethylamine; hepatitis C; HCV NS3; bioisostere; protease inhibitor.; NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry; NATURVETENSKAP Kemi Organisk kemi Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : This thesis describes work done to design and synthesize protease inhibitors, with the intention of developing therapeutic agents for Alzheimer’s disease (AD) and the chronic liver condition caused by infection of the hepatitis C virus (HCV). AD is the most common form of dementia, and HCV infection is the primary reason for liver transplantation in industrialized countries. LÄS MER

  4. 4. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors Incorporating a P2 Cyclopentane-Derived Scaffold

    Detta är en avhandling från Institutionen för fysik, kemi och biologi

    Författare :Marcus Bäck; Anja Sandström; [2006]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; HCV; NS3 protease; Proline mimic; Cyclopentane-derived scaffold; Linear inhibitors; Macrocyclic inhibitors; NATURAL SCIENCES Chemistry Organic chemistry Organic synthesis; NATURVETENSKAP Kemi Organisk kemi Organisk syntes;

    Sammanfattning : This thesis describes the design, synthesis and structure-activity relationships analysis of potential inhibitors targeting the hepatitis C virus (HCV) NS3 protease. Also discussed is the disease caused by HCV infection and the class of enzymes known as proteases. LÄS MER

  5. 5. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors Targeting Different Genotypes and Drug-Resistant Variants

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anna Karin Belfrage; Anja Sandström; Ulf Ellervik; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hepatitis C virus; HCV; NS3 protease inhibitors; structure-activity relationship; 2 1H -pyrazinone; quinazoline; resistance; Pd catalysis; Medicinal Chemistry; Läkemedelskemi; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Since the first approved hepatitis C virus (HCV) NS3 protease inhibitors in 2011, numerous direct acting antivirals (DAAs) have reached late stages of clinical trials. Today, several combination therapies, based on different DAAs, with or without the need of pegylated interferon-α injection, are available for chronic HCV infections. LÄS MER