Sökning: "ErbB3"

Visar resultat 6 - 10 av 15 avhandlingar innehållade ordet ErbB3.

1. 6. Affibody molecules targeting HER3 for cancer therapy

   Författare :Tarek Bass; Stefan Ståhl; Christina Furebring; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affibody molecule; cancer therapy; epidermal growth factor receptors; ErbB3; HER3; protein engineering;

   Sammanfattning : The development of targeted therapy has contributed tremendously to the treatment of patients with cancer. The use of highly specific affinity proteins to target cancer cells has become a standard in treatment strategies for several different cancers. LÄS MER

3. 7. Generation and characterization of Affibody molecules targeting HER3

   Författare :Magdalena Malm; Stefan Ståhl; Jennifer Cochran; KTH; []
   Nyckelord :Affibody molecules; epidermal growth factor receptors; HER3; ErbB3; combinatorial protein engineering; combinatorial library; staphylococcal surface display;

   Sammanfattning : In the field of oncology, the ability to target specific tumor cells using highly selective targeting molecules is an attractive and emerging concept. In this context, the epidermal growth factor receptor HER3 has proven central to the biology behind many different human cancers and inhibition of the signaling mediated by this receptor could provide antitumoral effects. LÄS MER

4. 8. An albumin-binding domain as a scaffold for bispecific affinity proteins

   Författare :Johan Nilvebrant; Sophia Hober; Andrew Bradbury; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; albumin-binding domain; bispecific; albumin; affinity protein; phage display; staphylococcal display; orthogonal affinity purification; TNF-alpha; ErbB2; ErbB3; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

   Sammanfattning : Protein engineering and in vitro selection systems are powerful methods to generate binding proteins. In nature, antibodies are the primary affinity proteins and their usefulness has led to a widespread use both in basic and applied research. LÄS MER

5. 9. On traumatic lesion to the spinal cord and dorsal spinal roots : factors influencing axonal regrowth across the border between the central and peripheral nervous system in the rat and man

   Författare :Tomas Lindholm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Immunohistochemistry; in situ hybridization; rat; man; axotomy; regeneration; motoneuron; ; CNS; PNS; tenascin; macrophages; BBB; scar; neuregulin; ErbB3 4; semaphorin; neuropilin; VEGF; olfactory system; DRG; DRT; SNT; SNC.;

   Sammanfattning : Nerve cells are depending on their environment. Glial cells, astrocytes and oligodendrocytes in the central nervous system (CNS) make up a totally different milieu and characteristics than the distinguishing qualities of the peripheral nervous system (PNS), where the nerve cells are surrounded by Schwann cells. LÄS MER

7. 10. Expression and prognostic value of LRIG1 and the EGF-receptor family in renal cell and prostate cancer

   Författare :Marcus Thomasson; Håkan Hedman; Roger Henriksson; Börje Ljungberg; Sten Nilsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; Renal cell carcinoma; EGFR; ErbB1-4; LRIG1; Oncology; Onkologi; onkologi; Oncology;

   Sammanfattning : The epidermal growth factor receptor (EGFR) family consists of four (EGFR, ErbB2, Erbb3, and ErbB4) receptor tyrosine kinases (RTK) whose signalling is important for physiological and malignant cellular functions such as proliferation, survival, migration, and differentiation. EGFR and ErbB2 in particular are established oncogenes in many solid tumours and are targets for anti-cancer treatment. LÄS MER