Sökning: "HER3"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet HER3.

  1. 1. Affibody molecules targeting HER3 for cancer therapy

    Författare :Tarek Bass; Stefan Ståhl; Christina Furebring; KTH; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affibody molecule; cancer therapy; epidermal growth factor receptors; ErbB3; HER3; protein engineering;

    Sammanfattning : The development of targeted therapy has contributed tremendously to the treatment of patients with cancer. The use of highly specific affinity proteins to target cancer cells has become a standard in treatment strategies for several different cancers. LÄS MER

  2. 2. Generation and characterization of Affibody molecules targeting HER3

    Författare :Magdalena Malm; Stefan Ståhl; Jennifer Cochran; KTH; []
    Nyckelord :Affibody molecules; epidermal growth factor receptors; HER3; ErbB3; combinatorial protein engineering; combinatorial library; staphylococcal surface display;

    Sammanfattning : In the field of oncology, the ability to target specific tumor cells using highly selective targeting molecules is an attractive and emerging concept. In this context, the epidermal growth factor receptor HER3 has proven central to the biology behind many different human cancers and inhibition of the signaling mediated by this receptor could provide antitumoral effects. LÄS MER

  3. 3. Affibody Molecules for HER3-targeted Theranostics of Malignant Tumours

    Författare :Maria Rosestedt; Anna Orlova; Vladimir Tolmachev; Olof Eriksson; Sten Nilsson; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; affibody molecules; theranostics; HER3; molecular imaging;

    Sammanfattning : The HER3 receptor plays a strong role in disease progression and resistance to therapies in several cancer types. Due to its endogenous expression and low overexpression in malignant tumours, it is a particularly challenging target. LÄS MER

  4. 4. Cellular Studies of HER-family Specific Affibody Molecules

    Författare :Lovisa Göstring; Lars Gedda; Jörgen Carlsson; Fredrik Frejd; Håkan Hedman; Uppsala universitet; []
    Nyckelord :EGFR; HER2; HER3; Affibody; internalisation; tumour targeting; MEDICINE; MEDICIN;

    Sammanfattning : The human epidermal growth-factor like receptor (HER) family of receptor tyrosine kinases are important targets for cancer therapy. The family consists of four members - EGFR, HER2, HER3 and HER4 - that normally transfer stimulatory signals from extracellular growth factors to the intracellular signalling network. LÄS MER

  5. 5. HER3 expression and prognosis in colon and rectal cancer

    Författare :Frida Lédel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Colorectal cancer;

    Sammanfattning : In Sweden, about 6000 patients get a colorectal cancer diagnosis annually. Advances in management of both colon and rectal cancer have reduced mortality even though the incidences are increasing. LÄS MER