Sökning: "Electrospray"

Visar resultat 16 - 20 av 151 avhandlingar innehållade ordet Electrospray.

  1. 16. Applications of nanospray desorption electrospray ionization mass spectrome : Analysis of lipids and metabolites in brain tissue sections and single cells

    Författare :Hilde-Marléne Bergman; Ingela Lanekoff; Jonas Bergquist; Leopold Ilag; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nano-DESI; single cell analysis; small molecule neurotransmitters; mass spectrometry imaging; MSI; GABA; Glutamate; Acetylcholine; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : .... LÄS MER

  3. 17. Advanced computations and mass-spectrometric techniques to unravel the dynamics and interactions of proteins

    Författare :Joana Costeira-Paulo; Erik Marklund; Lars Konermann; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molecular dynamics; mass spectrometry; dihydroorotate dehydrogenase; alpha-synuclein; protein structure; ion mobility; electrospray ionisation; collision cross section; lipids; gas-phase hydrogen deuterium exchange; collision induced unfolding; Biokemi; Biochemistry;

    Sammanfattning : Proteins are an important class of biomolecules, involved in the metabolism, regulation, structure and transport in cells. Unfortunately, many diseases are caused by protein dysfunction. When proteins perform their normal function, they may interact with each other or change their conformation. LÄS MER

  4. 18. From Solution into Vacuum - Structural Transitions in Proteins

    Författare :Alexandra Patriksson; David van der Spoel; Carol Robinson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; molecular dynamics; computer simulations; mass spectrometry; electrospray ionization; free-electron laser; vacuum structure of proteins; solvation; desolvation; single molecule imaging; Chemistry; Kemi;

    Sammanfattning : Information about protein structures is important in many areas of life sciences, including structure-based drug design. Gas phase methods, like electrospray ionization and mass spectrometry are powerful tools for the analysis of molecular interactions and conformational changes which complement existing solution phase methods. LÄS MER

  5. 19. Development and Investigations of Novel Sample Preparation Techniques : Electrochemical Extraction and Evaluation of Miniaturized Analytical Devices Coupled to Mass Spectrometry

    Författare :Gustav Liljegren; Leif Nyholm; Jean Pettersson; Per Sjöberg; Ari Ivaska; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Electrochemical extraction; Solid-phase microextraction; Solid-phase extraction; Microchip; Mass spectrometry; Polypyrrole; Pressurized-fluid extraction; Preconcentration; Electrospray ionization; Analytisk kemi; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Different sample preparation steps prior to a detection method are often essential in analytical chemistry. In this thesis, both static extractions and on-line coupled solid-phase extractions have been studied in combination with different detection techniques. LÄS MER

  7. 20. New methods for sensitive analysis with nanoelectrospray ionization mass spectrometry

    Författare :Patrik Ek; Johan Roeraade; Åsa Emmer; Andries P. Bruins; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; electrospray ionization; nanoelectrospray ionization; adjustable gap; emitter; miniaturization; improved sensitivity; nanoliter picoliter sample volumes; Alzheimer’s disease; amyloid-beta Aβ ; Analytical chemistry; Analytisk kemi;

    Sammanfattning : In this thesis, new methods that address some current limitations in nanoelectrospray mass spectrometry (nESI-MS) analysis are presented. One of the major objectives is the potential gain in sensitivity that can be obtained when employing the proposed techniques. LÄS MER