Sökning: "E. coli"

Visar resultat 26 - 30 av 711 avhandlingar innehållade orden E. coli.

  1. 26. Antiadhesive agents targeting uropathogenic Escherichia coli : Multivariate studies of protein-protein and protein-carbohydrate interactions

    Författare :Andreas Larsson; Jan Kihlberg; Fredrik Almqvist; Mats Larhed; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Antibacterial; pili; antiadhesive agents; structure based design; statistical molecular design; 2-pyridone; amino acid derivative; galabiose; enaminone; SPR; ELISA; QSAR; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis describes studies directed towards development of novel antiadhesive agents, with particular emphasis on compounds that prevent attachment of bacteria to a host-cell. Three different proteins involved in the assembly or function of adhesive pili in uropathogenic Escherichia coli have been targeted either by rational structure based design or statistical molecular methods. LÄS MER

  3. 27. Control of Proteolysis of Recombinant Proteins in Escherichia coli

    Författare :Aleksei Rozkov; KTH; []
    Nyckelord :proteolysis; recombinant protein; E. coli; bioprocess scale-up; protein A; ATP; sulfite; amino acids; growth inhibition; fed-batch culture; ZZT2;

    Sammanfattning : .... LÄS MER

  4. 28. Combinatorial Protein Engineering Of Affibody Molecules Using E. Coli Display And Rational Design Of Affibody-Based Tracers For Medical Imaging

    Författare :Ken G. Andersson; John Löfblom; Stefan Ståhl; Harald Kolmar; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; directed evolution; microbial display; E. coli; Affibody molecule; autotransporter; medical imaging; HER receptor family; Sortase A; Bioteknologi; Biotechnology;

    Sammanfattning : Directed evolution is today an established strategy for generation of new affinity proteins. This thesis describes the development of a cell-display method using Escherichia coli for directed evolution of Affibody molecules. LÄS MER

  5. 29. Structural Studies of Microbial Proteins - From Escherichia coli and Herpesviruses

    Författare :Daniel Gurmu; Heidi Erlandsen; Pär Nordlund; Arne O. Smalås; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CaiB; RibD; YhaK; SOX; ORF60; Herpesvirus; E. coli; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : Structure biology concerns the study of the molecular structures of biological macromolecules, such as proteins, and how these relate to the function. Protein structures are also of importance in structure-based drug design. In this thesis, the work has been carried out in two different projects. LÄS MER

  7. 30. Development and Application of ToF-SIMS for Clinical and Microbiological Analysis

    Författare :Kelly Dimovska Nilsson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ToF-SIMS; Imaging mass spectrometry; Antibiotic resistance; Basal cell carcinoma; Gas cluster ion beam; GCIB; Time-of-flight secondary ion mass spectrometry; BCC; Escherichia coli; E. coli; FabF; DapF; Lpp; Lipid A; ECAcyc; Depth profile;

    Sammanfattning : The aim of the work of this thesis was to further the implementation of timeof-flight secondary ion mass spectrometry (ToF-SIMS) in biological analysis and to generate new knowledge from the samples analysed. ToF-SIMS is a chemical analysis technique. LÄS MER