Sökning: "amino acid derivative"

Visar resultat 1 - 5 av 23 avhandlingar innehållade orden amino acid derivative.

1. 1. Macrocyclic Carbohydrate/Amino Acid Hybrid Molecules - Synthesis and Evaluation as Artificial Receptors

   Författare :Johan Billing; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 3-dipolar cycloaddition; 3-triazoles; 2; 1; molecular recognition; artificial receptors; sugar amino acids; cyclic peptides; macrocycles; Organic chemistry; Organisk kemi;

   Sammanfattning : Methods were developed for the synthesis of three different types of macrocyclic carbohydrate/amino acid hybrid molecules. In the synthesis of the first type of macrocycles, a glucosamine derivative was oxidized at C6 and the obtained sugar amino acid was coupled to tripeptides. LÄS MER

3. 2. Antiadhesive agents targeting uropathogenic Escherichia coli : Multivariate studies of protein-protein and protein-carbohydrate interactions

   Författare :Andreas Larsson; Jan Kihlberg; Fredrik Almqvist; Mats Larhed; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Antibacterial; pili; antiadhesive agents; structure based design; statistical molecular design; 2-pyridone; amino acid derivative; galabiose; enaminone; SPR; ELISA; QSAR; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis describes studies directed towards development of novel antiadhesive agents, with particular emphasis on compounds that prevent attachment of bacteria to a host-cell. Three different proteins involved in the assembly or function of adhesive pili in uropathogenic Escherichia coli have been targeted either by rational structure based design or statistical molecular methods. LÄS MER

4. 3. Asymmetric Formation and Isomerization of Three-Membered Rings : Catalyst Development and Evaluation

   Författare :Sophie Bertilsson; Tobias Rein; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; allylic alcohol; α-amino acid derivative; aza-Diels-Alder reaction; aziridination; cyclopropanation; desymmetrization; epoxide rearrangement; kinetic resolution; lithium amide; rhodium-carboxylate; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : Enantiopure α-amino acid derivatives were prepared using a protocol which allows for highly controlled regio- and chemoselectivity in the hydrogenation/ hydrogenolysis of aza-Diels-Alder adducts. One of the resulting α-amino esters, (1S,3R,4R)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid ethyl ester, was utilized further as a catalyst precursor. LÄS MER

5. 4. Synthesis of biomolecules for nuclide therapy : Studies on amino acids, nucleosides and isoquinolines

   Författare :Charlottta Naeslund; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : Nuclide therapy for cancer is based on the selective delivery of nuclide bearing compounds to tumour cells. Radionuclides, such as 125I, may be used, as well as stable isotopes, such as 10B, which is activated on site by an external neutron source. LÄS MER

7. 5. Synthesis of heterocycles from anthranilic acid and its derivatives

   Författare :Per Wiklund; Jan Bergman; Norbert de Kimpe; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Anthranilic acid; synthesis; heterocycles; benzodiazepines; HNO nitrosyl ;

   Sammanfattning : Anthranilic acid (2-aminobenzoic acid, Aa) is the biochemical precursor to the amino acid tryptophan, as well as a catabolic product of tryptophan in animals. It is also integrated into many alkaloids isolated from plants. Aa is produced industrially for production of dyestuffs and pharmaceuticals. LÄS MER