Sökning: "E. coli display"

Visar resultat 21 - 25 av 32 avhandlingar innehållade orden E. coli display.

  1. 21. Towards Anti-Virulence Antimicrobials, Discovery and Development of Sortase A Inhibitors and Investigations of Bacterial Phenotypes

    Författare :Patrick M. Wehrli; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Sortase A; SrtA; Inhibitors; Anti-virulence; Bacterial analysis; FTIR spectroscopy; Bacterial phenotyping; Design of Experiment; Multivariate Data Analysis; PCA; ToF-SIMS; Time-of-flight secondary-ion-mass-spectrometry; Lipid analysis; ppGpp; Stringent response;

    Sammanfattning : Antibiotic resistance is an emerging and serious threat to public health. Immediate actions are required to preserve current antibiotics while intensifying research efforts towards the development of new effective therapeutics. LÄS MER

  3. 22. Proteostasis in Bacillus subtilis : chaperones and stress-response mechanisms

    Författare :Judith Matavacas; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein homeostasis; Chaperones; DnaK; trigger factor; Spx; YjbH; Bacillus subtilis;

    Sammanfattning : The maintenance of protein homeostasis, also referred to as proteostasis, is essential for preserving the structural and functional stability of the proteome in living organisms. This involves the precise control of protein synthesis, folding, and degradation. LÄS MER

  4. 23. Bacteria-based methods for engineering and characterization of proteases and affinity proteins

    Författare :Lisa Sandersjöö; John Löfblom; Stefan Ståhl; Brent Iverson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioteknologi; Biotechnology;

    Sammanfattning : This thesis is focused on the development of methods for characterization and engineering of both proteases and affinity proteins. In addition, a prodrug concept for small affinity proteins is developed.Two of the developed methods are for engineering and/or characterization of proteases. LÄS MER

  5. 24. Construction, expression and evaluation of anti-keratin 8 single-chain antibody fragments

    Författare :Rozbeh Jafari; Birgitta Sundström; Jörgen Carlsson; Karlstads universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Single-chain antibody fragments; keratin 8; site-directed mutagenesis; heterologous expression; P. pastoris; design of experiments; multicellular tumor spheroids; immunotargeting; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : Antibodies are glycoproteins specifically binding to a variety of antigens and today extensively used in prevention, diagnosis and treatment of diseases. Carcinomas originate from epithelial tissues and are the most common forms of human malignancies. In the necrotic areas of carcinomas significant amounts of keratins (K) are found extracellularly. LÄS MER

  7. 25. Innate immune gene expression and function studied in insects and mammals

    Författare :Gang Liu; Ulrich Theopold; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mikrobiologi; Microbiology;

    Sammanfattning : Insects and mammals possess innate immune responses to effectively recognize and eliminate invading microorganisms. Insects, who share with mammals conserved molecules for immune defense, are good model systems for innate immunity studies. LÄS MER