Sökning: "Stringent response"

Visar resultat 1 - 5 av 48 avhandlingar innehållade orden Stringent response.

1. 1. The ribosome, stringent factor and the bacterial stringent response

   Författare :Rose-Marie Jenvert; Lovisa Holmberg Schiavone; Suparna Sanyal; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome; stringent factor; stringent response; tRNA; ribosomal protein L11; pppGpp; Cell biology; Cellbiologi; cellbiologi; Cellbiology;

   Sammanfattning : The stringent response plays a significant role in the survival of bacteria during different environmental conditions. It is activated by the binding of stringent factor (SF) to stalled ribosomes that have an unacylated tRNA in the ribosomal A-site which leads to the synthesis of (p)ppGpp. LÄS MER

3. 2. Functional studies of Escherichia coli stringent response factor RelA

   Författare :Ievgen Dzhygyr; Vasili Hauryliuk; Jörgen Johansson; Greg Bokinsky; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Stringent response; RelA; p ppGpp; ribosome; tRNA; metabolism regulation; allosteric regulation; translation; nutritional stress; molekylärbiologi; Molecular Biology;

   Sammanfattning : RelA is a ribosome associated multi-domain enzyme, which plays a crucial role in adaptation ofEscherichia coli to nutritional stress as such as amino acid deficiency. It detects the deficiency of aminoacids in the cell by monitoring whether a tRNA at the acceptor site (A-site) of the ribosome is chargedwith amino acid or not. LÄS MER

4. 3. Genetics and Growth Regulation in Salmonella enterica

   Författare :Jessica M. Bergman; Diarmaid Hughes; Dan I. Andersson; Måns Ehrenberg; Stanley Maloy; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tufA; tufB; EF-Tu; ppGpp; Stringent response; RNase E; RNA turnover; Post-transcriptional regulation; rpoB; rpoS; Growth in stationary phase; Biology with specialization in Microbiology; Biologi med inriktning mot mikrobiologi; Mikrobiologi; Microbiology; Molekylär genetik; Molecular Genetics; Biology with specialization in Molecular Evolution; Biologi med inriktning mot molekylär evolution;

   Sammanfattning : Most free-living bacteria will encounter different environments and it is therefore critical to be able to rapidly adjust to new growth conditions in order to be competitively successful. Responding to changes requires efficient gene regulation in terms of transcription, RNA stability, translation and post-translational modifications. LÄS MER

5. 4. Towards Anti-Virulence Antimicrobials, Discovery and Development of Sortase A Inhibitors and Investigations of Bacterial Phenotypes

   Författare :Patrick M. Wehrli; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Sortase A; SrtA; Inhibitors; Anti-virulence; Bacterial analysis; FTIR spectroscopy; Bacterial phenotyping; Design of Experiment; Multivariate Data Analysis; PCA; ToF-SIMS; Time-of-flight secondary-ion-mass-spectrometry; Lipid analysis; ppGpp; Stringent response;

   Sammanfattning : Antibiotic resistance is an emerging and serious threat to public health. Immediate actions are required to preserve current antibiotics while intensifying research efforts towards the development of new effective therapeutics. LÄS MER

7. 5. The Importance of a Fifth Element in Transcription: Transcriptional Discrimination in Escherichia coli

   Författare :Bertil Gummesson; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; RNA polymerase; ppGpp; DksA; stringent response; passive regulation;

   Sammanfattning : Upon growth arrest of the bacterium Escherichia coli, RNA polymerase (Es70) is redirected from transcribing genes encoding the protein synthesizing system (PSS) to those involved in maintenance and stress resistance. The small nucleotide ppGpp, which is directly targeting Es70, is a key regulatory molecule required for this response. LÄS MER