Sökning: "Protein homeostasis"

Visar resultat 1 - 5 av 427 avhandlingar innehållade orden Protein homeostasis.

  1. 1. Exploring small heat shock protein chaperones by crosslinking mass spectrometry

    Författare :Wietske Lambert; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cross-linking; mass spectrometry; protein-protein interactions; Hsp21; BS3; DTSSP; MALDI-TOF TOF; client protein; substrate; aggregation; unfolded protein; chaperone; Small heat shock protein; crosslinking;

    Sammanfattning : Together with other molecular chaperones, small heat shock proteins are key components of the protein quality control system, which is comprised of several hundred proteins and acts to maintain proteome homeostasis in the cell. Small heat shock proteins bind unfolding proteins at an early stage, to prevent these from further unfolding and aggregating. LÄS MER

  3. 2. p63 and epithelial homeostasis : studies of p63 under normal, hyper-proliferative and malignant conditions

    Författare :Xiaolian Gu; Karin Nylander; Antonio Costanzo; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; p63; psoriasis; SCCHN; epithelium; homeostasis; Pathology; Patologi; patologi; Pathology;

    Sammanfattning : Background: The p63 gene is a member of the p53 transcription factor family and can produce six different proteins using two promoters and differential splicing. Expression of p63 is required for proper formation of epithelial tissues. LÄS MER

  4. 3. Human Aquaporins: Production, Characterization and Interactions

    Författare :Jennie Sjöhamn; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aquaporins; membrane protein; protein production; protein characterization; protein:protein interactions; structural biochemistry;

    Sammanfattning : Membrane proteins are essential components of the cell and responsible for the communication with the outside environment and transport of molecules across the membrane. Water transport is facilitated by aquaporins, which are water selective transmembrane pores that serve to maintain cell homeostasis. LÄS MER

  5. 4. Protein-Protein Interactions in Human Aquaporin Regulation

    Författare :Jennifer Virginia Roche; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Membrane proteins; Human Aquaporins; water channels; Protein-protein interaction; Regulation; AQP2; AQP0; LIP5; CaM;

    Sammanfattning : Water is an essential compoment of every living orgamism and forms a major part of the human body. Regulated water transport is crucial for proper cell functioning and body homeostasis. LÄS MER

  7. 5. Interorganellar connectivity : From protein to lipid homeostasis

    Författare :Carlotta Peselj; Sabrina Büttner; Tim Levine; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Interorganellar connectivity; nucleus; NVJs; chronic lipid bilayer stress; glucose and phosphate exhaustion; nutritional regimes; transmembrane chaperone; IPTP; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Interorganellar connectivity is fundamental for the maintenance of organellar and cellular functionality and viability. This is achieved and maintained by a complex network of signaling cascades, vesicle trafficking between organelles as well as by establishment of direct physical contact at membrane contact sites (MCS). LÄS MER