Sökning: "Dyskinesias"

Visar resultat 11 - 15 av 16 avhandlingar innehållade ordet Dyskinesias.

1. 11. Mobile systems for monitoring Parkinson's disease

   Författare :Mevludin Memedi; Mark Dougherty; Silvia Coradeschi; Peter Funk; Jerker Westin; Martin Gellerstedt; Örebro universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; automatic assessments; data visualization; data-driven modelling; home assessments; information technology; mobile computing; objective measures; Parkinson’s disease; quantitative assessments; remote monitoring; spirography; symptom severity; tapping tests; telemedicine; telemetry; time series analysis; web technology; Information technology; Informationsteknologi; Datavetenskap; Computer Science; PAULINA - Uppföljning av Parkinsonsymptom från hemmet;

   Sammanfattning : A challenge for the clinical management of Parkinson's disease (PD) is the large within- and between-patient variability in symptom profiles as well as the emergence of motor complications which represent a significant source of disability in patients. This thesis deals with the development and evaluation of methods and systems for supporting the management of PD by using repeated measures, consisting of subjective assessments of symptoms and objective assessments of motor function through fine motor tests (spirography and tapping), collected by means of a telemetry touch screen device. LÄS MER

3. 12. Models and biomarkers of motor and neuropsychiatric complications in Parkinson’s disease

   Författare :Katrine Skovgård; Basala gangliernas patofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease Parkinsonism; Dyskinesia; Drug-Induced; Oscillations; Local field potentials; Impulsive-compulsive behaviours; Dopamine agonists; Animal Models; Pharmacology;

   Sammanfattning : Parkinson's disease (PD) is a neurodegenerative disorder characterised by typicalmotor symptoms that are caused by severe dopamine depletion in the cortico-basalganglia network. Parkinsonian motor symptoms are improved by dopaminergicmedications, the most effective being the dopamine precursor L-DOPA. LÄS MER

4. 13. Behavioural and biochemical pharmacology of adenosine/dopamine receptor/receptor interaction

   Författare :Roberto Rimondini-Giorgini; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adenosine; A; receptors; A2A receptors; dopamine; D1 receptors; D2 receptors; mGluR receptors; striatum; immediately early genes; c-fos; junB; NGFI-A; microdialysis; receptor binding; in situ hybridisation;

   Sammanfattning : The neurotransmitter dopamine seems to be involved in neuropsychiatric diseases such as schizophrenia and Parkinson's disease. Direct blockade of dopamine receptors of the D2 subtype has been the hallmark of pharmacotherapy for schizophrenia since early 1950s. LÄS MER

5. 14. The non-human primate as a model of human parkinsonism

   Författare :Alison McCormack; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Parkinson s disease; substantia nigra; aging; neuromelanin; MPTP; alpha-synuclein; levodopa; dyskinesia; methamphetamine;

   Sammanfattning : The motor deficits seen in Parkinson’s disease (PD) are the result of a loss of catecholaminergic neurons from the substantia nigra (SN) and the associated loss of striatal dopamine. Clinical signs become evident once striatal dopamine levels decline by at least 70-80% and nigral cell numbers by 40%, and worsen with increased duration of the disease. LÄS MER

7. 15. Neuropharmacological studies of Parkinson's disease with some emphasis on serotonin transmission

   Författare :Xiaoqun Zhang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by hypokinesia, rigidity, tremor, gait disturbances and depression. There is an accumulative of protein aggregates, Lewy bodies, which appear to begin in the brainstem and progress caudorostrally. LÄS MER