Sökning: "NGFI-A"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet NGFI-A.

  1. 1. Estrogen signaling in stroke : genetic and experimental studies

    Författare :Magnus Strand; Tommy Olsson; Jan Hillert; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; intracerebral hemorrhage; ischemic stroke; genetics; ERα; OPG; 17β-estradiol; enriched environment; learning and memory; hippocampus; NGFI-A; Medicine; Medicin;

    Sammanfattning : Stroke is a common and multifactorial disease influenced by genetic and environmental risk factors. It is a highly heterogeneous entity consisting of two main types, ischemic (80%) and hemorrhagic (20%) stroke. The most common form of hemorrhagic stroke is intracerebral hemorrhage (ICH). LÄS MER

  3. 2. Striatal adenosine A2A receptors

    Författare :Per Svenningsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :caffeine; adenosine; A2A receptors; dopamine receptors; striatum; basal ganglia; immediate early genes; c-fos; NGFI-A; DARPP-32; in situ hybridization;

    Sammanfattning : The nucleoside adenosine exerts a modulatory action in the central nervous system by activating G-protein coupled receptors. Four such receptors are cloned and pharmacologically characterized: A1, A2A, A2B and A3. Caffeine, the most widely consumed psychostimulant, acts as an adenosine receptor antagonist predominantly on the first two. LÄS MER

  4. 3. Behavioural and biochemical pharmacology of adenosine/dopamine receptor/receptor interaction

    Författare :Roberto Rimondini-Giorgini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adenosine; A; receptors; A2A receptors; dopamine; D1 receptors; D2 receptors; mGluR receptors; striatum; immediately early genes; c-fos; junB; NGFI-A; microdialysis; receptor binding; in situ hybridisation;

    Sammanfattning : The neurotransmitter dopamine seems to be involved in neuropsychiatric diseases such as schizophrenia and Parkinson's disease. Direct blockade of dopamine receptors of the D2 subtype has been the hallmark of pharmacotherapy for schizophrenia since early 1950s. LÄS MER

  5. 4. Post-Ischemic Housing Conditions Influence On Gene Transcription And Translation After Permanent Focal Brain Ischemia In Rats

    Författare :Li-Ru Zhao; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rats; brain-derived neurotrophic factor; mRNA; nerve growth factor-induced gene A; corticosteroid receptors; in situ hybridization; Neurologi; neurophysiology; Neurology; neuropsychology; brain ischemia; enriched environment; neuropsykologi; neurofysiologi;

    Sammanfattning : Enriched environment (EE) housing significantly ameliorates neurological deficits induced by cortical brain ischemia without changing infarction size, suggesting that EE-related functional benefits are associated with neuronal plasticity events in the remaining tissue. Brain-derived neurotrophic factor (BDNF), nerve growth factor-induced gene A (NGFI-A) and corticosteroid receptors (mineralocorticoid receptor, MR; glucocorticoid receptor, GR) have been demonstrated to be involved in brain plasticity. LÄS MER

  7. 5. Stroke and Functional Recovery - An experimental study on environmental influence and gene expression after cortical infarcts in the rat

    Författare :Anette Risedal; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; cortical infarct; rat; enriched environment; functional recovery; brain-derived neurotrophic factor; inducible transcription factors; neuropsykologi; neurofysiologi; Neurologi; glucocorticoids; neurophysiology;

    Sammanfattning : Abstract Stroke is the third leading cause of death in the western world, and the number one cause of disability. 85% of all strokes are ischemic. Most stroke survivors will experience recovery of function. The mechanisms behind this improvement are partly unknown, but may involve elements of both compensation and restoration. LÄS MER