Sökning: "Complex transcription"

Visar resultat 1 - 5 av 461 avhandlingar innehållade orden Complex transcription.

  1. 1. The SWI/SNF complex : Roles in transcription and pre-mRNA processing

    Författare :Johan Waldholm; Neus Visa; Ann-Kristin Östlund; Silvia Barabino; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Splicing; Gene regulation; SWI SNF; polyadenylation; molekylärbiologi; Molecular Biology;

    Sammanfattning : The regulation of gene expression is fundamental to the development of complex organisms and an important driving force in this process. When and where the genes are expressed decide the fate of a cell and its physiological context in the organism. LÄS MER

  2. 2. From Single Gene to Whole Genome Studies of Human Transcription Regulation

    Författare :Alvaro Rada-Iglesias; Claes Wadelius; Henk Stunnenberg; Uppsala universitet; []
    Nyckelord :Genetics; transcription; ChIP-chip; genome-wide; transcription factors; in vivo; Genetik;

    Sammanfattning : Transcriptional regulation largely determines which proteins and the protein levels that are found in a cell, and this is crucial in development, differentiation and responses to environmental stimuli. The major effectors of transcriptional regulation are a group of proteins known as transcription factors, which importance is supported by their frequent involvement in mendelian and complex diseases. LÄS MER

  3. 3. Gene regulation during development by chromatin and the Super Elongation Complex

    Författare :Olle Dahlberg; Mattias Mannervik; Peter Gergen; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Drosophila development; gene regulation; transcription; chromatin; P-TEFb; Super Elongation Complex; KDM4A; H3K36me3; H3K14ac; histone replacement; utvecklingsbiologi; Developmental Biology;

    Sammanfattning : Developmental processes are carefully controlled at the level of transcription to ensure that the fertilized egg develops into an adult organism. The mechanisms that controls transcription of protein-coding genes ultimately ensure that the Pol II machine synthesizes mRNA from the correct set of genes in every cell type. LÄS MER

  4. 4. Maf transcription factors in beta cell function

    Författare :Elvira Ganic; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Beta cell; MafA; type 2 diabetes; insulin secretion; transcription; monoamine oxidase; MaoA; MaoB; nicotinic receptor subunits; nAChRs;

    Sammanfattning : Diabetes mellitus is metabolic disorder caused by a defect or lack of beta cell-produced insulin that controls blood glucose homeostasis. In addition to glucose, insulin secretion is regulated by the autonomic nervous system (ANS); the neurotransmitter acetylcholine as well as monoamines, such as dopamine, serotonin, melatonin and norepinephrine. LÄS MER

  5. 5. Signals and Noise in Complex Biological Systems

    Författare :Johan Rung; Erkki Brändas; Måns Ehrenberg; Uppsala universitet; []
    Nyckelord :Engineering physics; complex systems; computational biology; gene networks; genome-wide; stochastic resonance; microarray; diabetes; association study; transcription regulation; gene expression; Teknisk fysik;

    Sammanfattning : In every living cell, millions of different types of molecules constantly interact and react chemically in a complex system that can adapt to fluctuating environments and extreme conditions, living to survive and reproduce itself. The information required to produce these components is stored in the genome, which is copied in each cell division and transferred and mixed with another genome from parent to child. LÄS MER